OCTive: A New Horizon in MS Digital Solution
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Multiple Sclerosis. Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Measuring Motor Symptoms in Clinical Conditions OR Objective Measures to Monitor the Progression of Motor Symptoms of Clinical Conditions
Overview
Multiple Sclerosis (MS) is a condition that affects the brain and spinal cord, leading to problems with movement, balance, and vision. This project will validate innovative tools developed for monitoring MS progression using advanced movement analysis and retinal imaging technologies. Two computer vision-based applications, Digi Motion and Digi Balance, will measure range of motion, centre of mass, balance, and stability. In parallel, a model will be trained to analyse eye images using Optical Coherence Tomography (OCT)-a non-invasive technique that captures detailed views of retinal structures, including the retinal nerve fibre layer (RNFL), ganglion cell-inner plexiform layer (GC-IPL), and macular thickness, which are key biomarkers of MS-related neuroaxonal loss. These tools will be evaluated in people with MS, comparing results with traditional clinical assessments to determine reliability and validity. By integrating movement and retinal biomarkers, this approach aims to create a comprehensive and personalised method for tracking disease progression.
Detailed description
clinical investigation
Primary outcome measures
- Agreement and reliability between DigiBalance quantitative physical function metrics and standard clinical assessments [Time frame: Baseline]
Secondary outcome measures (3)
- Feasibility of the practicality of conducting the integrated digital assessment battery within a laboratory setting [Time frame: Baseline]
- Feasibility of the practicality of conducting the integrated digital assessment battery within a laboratory setting [Time frame: Baseline]
- Usability of the interfaces, comfort, and clarity of instructions [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
- condition has been stable over a period of a month
- can walk at least 10 metres independently with or without their walking aids
Exclusion criteria
- pregnancy
- allergic to adhesive materials
- a condition that precludes safe participation in the assessment as indicated by the referring clinician
- insufficient mental capacity to consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United Kingdom · 1 center
- University of Exeter Engineering Research Centre — Exeter
Identifiers
NCT: NCT07582653 · 67269