MOLyF : Bone Marrow and Follicular Lymphoma
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Sampling.
- Who it may be relevant to
- Registry conditions: Lymphoma, Follicular. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Bone Marrow and Follicular Lymphoma
Overview
This is a prospective single-center study designed to assess potential differences in cell composition between bone marrows of patients with follicular lymphoma and those from control subjects. Follicular lymphoma is the most common indolent lymphoma. It is characterised by systematic relapses and bone marrow dissemination in 70% of patients at the time of diagnosis. Although relapses are thought to be related to refractory tumour cells nested in a supportive microenvironment in the bone marrow, the mechanisms involved are poorly understood. To study the specificities of the bone marrow of patients with follicular lymphoma, It is necessary to compare them with control samples. This study takes advantage of surgeries involving sternotomies to recover lost bone marrow and establish a bone marrow bank of patients without hematological disease. This bank will be used to set up control cohorts for other clinical trials involving patients with follicular lymphoma.
Interventions
- Other Sampling
sternal bone marrow aspiration
Primary outcome measures
- Flow cytometric quantification of cell populations [Time frame: 1 day]
Eligibility criteria
Inclusion criteria
- Major patient
- Patient hospitalized in the thoracic, cardiac and vascular surgery department for surgery involving a sternotomy
- Patient with free, informed, written consent
- Patient covered by a health insurance scheme
Exclusion criteria
- History of haematological malignancy or haemogram disturbance
- Immunomodulating treatment: immunosuppressants, corticoids, antineoplastics
- Persons covered by articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French Public Health Code (e.g. minors, protected adults, etc.)\].
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
France · 1 center
- CHU Rennes — Rennes
Identifiers
NCT: NCT06608147 · 35RC24_9716_MOLyF