An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Lung Cancer. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The goal of this observational study is to improve the early detection of lung cancer in adults who have smoked less than 100 tobacco cigarettes ("never-smokers") in the United Kingdom. The main questions it aims to answer are: * To describe characteristics such as demographics, co-morbidities and environmental exposures * To describe participant pathways including presentation mode and symptoms to understand if earlier diagnosis would be possible * To describe participant outcomes such as cancer stage, treatment and mortality * To quantitatively or qualitatively measure modifiable and non-modifiable factors that may be associated with LCINS including environmental measures, blood tests and genomic data. Participants will currently have no change to their usual care.
Primary outcome measures
- Demographics, comorbidities and environmental exposures of participants [Time frame: Comorbidities and environmental exposures at diagnosis (approximately up to 156 weeks prior to diagnosis)]
- Participant pathways including presentation mode and symptoms [Time frame: Presentation mode and symptoms at time of diagnosis (approximately up to 52 weeks prior to diagnosis)]
Secondary outcome measures (2)
- Participant outcomes such as cancer stage, treatment, mortality [Time frame: Cancer stage at time of diagnosis, treatment and mortality through study completion (likely 5 years)]
- Measurement of modifiable and non-modifiable factors associated with LCINS [Time frame: Through study completion (likely 5 years)]
Eligibility criteria
Inclusion criteria
- All adult participants from age of 18 who are diagnosed or treated with primary lung cancer through radiology or histology at any participating study site
Exclusion criteria
- Participants who have ever smoked cigarettes or tobacco will be excluded; this is defined as:
- More than 100 cigarettes or 75g tobacco in their lifetime
- Those who have received a prescription for nicotine replacement therapy
- For prospective participants, those who cannot consent will be excluded
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United Kingdom · 1 center
- University College London Hospital — London
Identifiers
NCT: NCT06575439 · 159292