An Observational Study of Patients Living With Chronic Neurological Diseases
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Neurological Diseases or Conditions, Dementia of Alzheimer Type, Alzheimer Disease, Mild Cognitive Impairment. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
TARGET-NEURO is an observational research study to conduct a comprehensive review of outcomes for patients living with chronic neurological diseases: Alzheimer's disease and related dementia (ADRD), mild cognitive impairment (MCI), Parkinson's disease (PD), and multiple sclerosis (MS).
Primary outcome measures
- To characterize the natural history of disease in patients living with chronic neurological diseases including ADRD, MCI, PD, or MS [Time frame: 15 Years]
- To assess safety and effectiveness of disease treatments and treatments for complications of patients receiving various treatments, effectiveness of treatment, and medical events that develop while receiving treatment for ADRD, MCI, PD, or MS. [Time frame: 15 Years]
Secondary outcome measures (3)
- To evaluate provider management practices in the treatment of patients living with ADRD, MCI, PD, or MS [Time frame: 15 Years]
- To evaluate longitudinal and patient and care partner reported outcomes in patients with ADRD, MCI, PD, or MS, including care partner burden and quality of life. [Time frame: 15 Years]
- 3. To select and evaluate quality of care measures for patients living with ADRD, MCI, PD, or MS [Time frame: 15 Years]
Eligibility criteria
Disease Cohort
Inclusion criteria
•Adult patients at the time of enrollment with a diagnosis of ADRD, MCI, PD, or MS by select ICD-10 codes in the EHR interface
Exclusion criteria
- Death
- Manual removal (sponsor or site request)
- No EHR interface encounter > 3 years
Engaged Cohort
Inclusion criteria
- Adult patients diagnosed and managed for these conditions invited to participate
- Ability to provide written informed consent (or have a legally authorized representative to provide informed consent)
- Care partners may be invited to participate in surveys and will provide informed consent.
Exclusion criteria
- Patient expressed desire to withdraw consent to complete PROs
- Care partner expressed desire to withdraw consent to complete PROs
- Failure to complete PROs within 24 weeks of initial invitation
- Greater than 24 months lapse of survey completion after baseline surveys completed
- Additionally, the criteria detailed for Disease Cohort apply to the Engaged Cohort
Age Cohort
Inclusion criteria
•Adult patients aged 60 and older at time of enrollment
Exclusion criteria
- Death
- Manual removal (sponsor or site request)
- No EHR interface encounter > 3 years
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT05796037 · TARGET-NEURO