Lung cancer — clinical trials

Not yet recruiting NCT06739421

The Diagnostic Value of Bronchoscopic Needle-based Confocal Laser Endomicroscopy (nCLE) As a Real-time Detection Tool for Diagnosing Peripheral Lung Cancer: a Multi-centre Randomised Controlled Trial

No phase Interventional China

Lung Cancer, Non-Small Cell · Lung Cancer, Small Cell

Not yet recruiting NCT06738680

PRedictive Value of Multiparametric Dynamic WB 18F-FDG-PET Imaging on a LAFOV System for FIRST-line Chemo-immunotherapy Efficacy in Advanced Non-small-cell Lung Cancer: PROFIL-1

— Observational France

Non-Small Cell Lung Cancer

Recruiting NCT06739928

Irinotecan Liposome (II) or Etoposide Combined With Adebrelimab and Carboplatin in the Treatment of ES-SCLC

Phase II Interventional China

Small Cell Lung Cancer Extensive Stage

Recruiting NCT06737107

Multicenter Analysis of Different Approaches in Segmentectomies in Early-stage Lung Cancer

— Observational Italy

Early Stage Lung Cancer (I and II) · Non-Small Cell Lung Cancer

Not yet recruiting NCT06735508

MRNA Neoantigen Vaccine in Non-Small Cell Lung Cancer

Early Phase I Interventional China

NSCLC

Recruiting NCT06252233

Improvement of Quality of Life (QoL) Using Preference-Oriented QoLMonitoring in Patients with Lung Cancer

No phase Interventional Germany

Lung Cancer · Quality of Life

Recruiting NCT06440057

Dose Escalation Study of ZG006 in Participants With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma, Followed by Dose Expansion Study in Participants With Neuroendocrine Carcinoma.

Phase I / Phase II Interventional China

Neuroendocrine Carcinoma

Recruiting NCT06735391

A Clinical Study of JMT101 in Combination With Osimertinib Versus Osimertinib Alone as First-Line Treatment for Patients With Locally Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC) Harboring Epidermal Growth Factor Receptor (EGFR) Sensitive Mutations

Phase III Interventional China

Locally Advanced or Metastatic Non-squamous NSCLC · Harboring EGFR Sensitive Mutations NSCLC · Previously Untreated Systematically NSCLC

Recruiting NCT06734182

Neoadjuvant Envafolimab Plus Disitamab Vedotin and Carboplatin in Resectable HER2-Mutant Non-Small-Cell Lung Cancer

Phase II Interventional China

Non-small Cell Lung Cancer

Not yet recruiting NCT06704620

Study of Tislelizumab and Platinum-based Chemotherapy Combination With H1 Receptor Antagonist（Diphenhydramine）in Advanced and Metastatic Non-Small Cell Lung Cancer

Phase III Interventional China

Advanced and Metastatic NSCLC

Recruiting NCT06467617

Adebrelimab Plus Chemo and Recaticimab in Perioperative Treatment of Resectable NSCLC

Phase II Interventional China

Non Small Cell Lung Cancer

Recruiting NCT04170634

Tumoral Bone Strength Assessment by Numerical Simulation Using Quantitative CT : the MEKANOS Study

— Observational France

Metastases to Bone · Metastatic Breast Cancer · Metastatic NSCLC

Not yet recruiting NCT06725225

Machine Learning for Predicting and Managing Quality of Life in Lung Cancer Immunotherapy Patients

No phase Interventional —

Lung Cancer Patients

Recruiting NCT06668103

A Phase 2 Clinical Study of Combination Therapy With ABSK043 and Firmonertinib

Phase II Interventional China

Non-Small Cell Lung Cancer With EGFR Mutation

Enrolling by invitation NCT06730477

Plasma Exosomes Reveal the Efficacy of Targeted Therapy in Patients With EGFR Mutation in Lung Adenocarcinoma

— Observational China

Lung Adenocarcinoma · EGFR Activating Mutation

Recruiting NCT06496048

Lurbinectedin or in Combination with Irinotecan Versus Topotecan in Patients with Relapsed SCLC

Phase III Interventional China

Relapsed Small Cell Lung Cancer

Enrolling by invitation NCT06647836

The Therapeutic Effect of Immunotherapy in Patients With Advanced Lung Squamous Carcinoma

— Observational China

Squamous Cell Lung Cancer

Recruiting NCT06575439

An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK

— Observational United Kingdom

Lung Cancer

Recruiting NCT06730503

Glycoprotein in Immunotherapy Response and Efficacy Prediction of Lung Cancer

— Observational China

Non Small Cell Lung Cancer

Recruiting NCT03667027

Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant

— Observational Canada

Diaphragm Injury · Respiratory Failure · Mechanical Ventilation Complication

Recruiting NCT06728852

Efficacy and Safety of Vorolanib Monotherapy As Third-line or Later Treatment for Advanced Non-small Cell Lung Cancer Patients: a Single-arm, Prospective, Open-label Phase II Clinical Study

Phase II Interventional China

Advanced Non-small Cell Lung Cancer (NSCLC) · Recurrent or Metastatic Lung Cancer · Third-line and Beyond Therapy

Recruiting NCT05642832

Feasibility of Reducing Respiratory Drive Using the Through-flow System

No phase Interventional Canada

Respiratory Insufficiency · Diaphragm Injury · Lung Injury

Recruiting NCT05349227

Comprehensive Outcomes for After Cancer Health

No phase Interventional United States

Ovarian Cancer · Breast Cancer · Lung Cancer

Recruiting NCT06728865

Evaluation of the Efficacy and Safety of Furmonertinib Combined with Bevacizumab As First-Line Treatment for EGFR-Positive Non-Small Cell Lung Cancer with Brain Metastases: a Single-Arm, Open-Label, Prospective Phase II Clinical Study

Phase II Interventional China

Non-small Cell Lung Cancer (NSCLC) · EGFR Mutation-Positive Lung Cancer · Brain Metastases

Recruiting NCT06019455

The Level of Patient Participation in Lung and Esophageal Cancer Patients Treated With Definitive Radiochemotherapy.

— Observational China

Lung Cancer · Esophageal Cancer

Recruiting NCT06726564

A Study of MT027 in Patients with Pleural Malignant Tumors

Phase I Interventional China

Advanced Malignant Solid Tumor · Malignant Pleural Effusion · Pleura Carcinoma

Recruiting NCT06727370

Cognitive Screening in Lung Cancer Patients

— Observational Italy

Lung Disease · NSCLC (Non-small Cell Lung Cancer) · SCLC

Recruiting NCT06423690

First in Human Study for the Assessment of Safety and Initial Performance of the EAS1 System

No phase Interventional Israel, Spain +1

Lung Cancer

Not yet recruiting NCT06716008

Manual Diaphragmatic Release on Ventilatory Functions in Women With Rheumatoid Arthritis

No phase Interventional —

Rheumatic Arthritis · Lung Function

Recruiting NCT06377449

Influence of Lung Ultrasonography on the Prognosis and Postoperative Outcomes in Cardiac Surgical Patients

No phase Interventional Russia

Ischemic Heart Disease · Aortic Stenosis, Severe · Aortic Insufficiency

Not yet recruiting NCT06724263

A Multicenter, Open-label Phase IIa Clinical Study to Evaluate the Efficacy and Safety of B1962 Injection in the Treatment of Advanced Malignant Solid Tumors

Phase II Interventional China

Recurrent Platinum-resistant Epithelial Ovarian Cancer · Triple Negative Breast Cancer (TNBC) · Cervical Cancers

Recruiting NCT06412289

Comparison of the Diagnostic Accuracy: US-guided Percutaneous Lung Biopsies vs CT-guided in Peripheral Lung Lesions

No phase Interventional Italy

Peripheral Lung Lesions

Recruiting NCT06032273

Lung Transplant READY CF 2: CARING CF Ancillary RCT

No phase Interventional United States

Cystic Fibrosis

Recruiting NCT06718309

Chemotherapy Plus Immunotherapy Combined With SBRT as Neoadjuvant Therapy for Patients With Resectable NSCLC

Phase II Interventional China

Non-Small Cell Lung Cancer

Not yet recruiting NCT06719336

Addition of Thoracic Consolidation Radiotherapy to the Maintenance Immunotherapy for ES-SCLC (STONE-001)

Phase III Interventional —

Extensive-stage Small Cell Lung Cancer

Not yet recruiting NCT06716775

Tumor Treating Fields (TTF) in Combination with Stereotactic Radiosurgery(SRS) for Brain Metastases from Non-small Cell Lung Cancer.

No phase Interventional —

NSCLC Brain Metastasis

Not yet recruiting NCT06259357

Prone Positioning in Neurologically Deceased Potential Organ Donors to Improve Donor Lung Function and Lung Transplant Recipient Outcomes

No phase Interventional Canada

Lung Transplant Failure

Recruiting NCT05973201

Evaluation of Virtual Reality to Reduce Anxiety, Pain and Duration of Non-emergency Vigile Bronchial Fibroscopy (AVATAR)

No phase Interventional France

Respiratory Disorder · Lung Infection

Recruiting NCT06206850

Neo-Bio-ADAURA: a Phase II Study to Evaluate Mechanisms of Resistance to Neoadjuvant Osimertinib

Phase II Interventional Israel

Non-squamous NSCLC

Recruiting NCT06644430

Ablation of Pulmonary Oligometastasis Combined With System for Advanced Hepatocellular Carcinoma

— Observational China

Advanced Hepatocellular Carcinoma · Lung Cancer · Oligometastasis

Recruiting NCT03578185

Genomic Analysis to Identify a Predictive Biomarker for Immunotherapy

— Observational South Korea

Lung Cancer

Recruiting NCT06713187

Interleukin23 in Systemic Lupus

No phase Interventional Egypt

Systemic Lupus Erythematosus Related Interstial Lung Disease

Not yet recruiting NCT06310993

Exercise to Boost Immunity in Advanced Cancer

No phase Interventional United Kingdom

Mesothelioma; Lung · Pancreatic Cancer

Recruiting NCT06713512

InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease

— Observational United Kingdom

Chronic Obstructive Lung Disease · Respiratory Ilness · Estrogen Deficiency

Recruiting NCT05598528

Exploring the Mechanism of Primary Resistance to Third-generation EGFR-TKIs as First-line Treatment in EGFR-positive Advanced NSCLC (PRECISE Study)

— Observational China

Lung Cancer, Non-small Cell · EGFR Gene Mutation · EGFR-TKI Resistant Mutation

Not yet recruiting NCT06458673

A Prospective, Non-interventional Cohort Study of Subsolid Pulmonary Nodules

— Observational China

Solitary Lung Nodule · Multiple Pulmonary Nodules

Not yet recruiting NCT06711939

Vocorder Device Validation in Clinical Settings - Continuous Monitoring of Individuals (Vocorder Clinical Validation-VCV)

— Observational Greece

Cancer of the Breast · Cancer of Stomach · Colon Cancer

Not yet recruiting NCT06218069

Immuno-pet IMaging ResPonses AdministeRed Immune CheckpoiNt InhibiTor

Phase II / Phase III Interventional Germany, Netherlands

NSCLC

Recruiting NCT05945745

Molecular Analysis and Treatment Options of SCLC

— Observational China

Small-cell Lung Cancer · Small Cell Lung Cancer, Combined Type · Small Cell Lung Carcinoma

Recruiting NCT06451029

Prevention of Smoking Related Diseases

— Observational Italy

Lung Cancer · Lung Cancer Screening · Smoking Cessation

Not yet recruiting NCT06709274

Minimal Residual Disease Guiding Adjuvant Therapy in Stage I NSCLC

No phase Interventional China

Non-Small Cell Lung Cancer

Recruiting NCT00471978

DNA Analysis of Blood and Tissue from Patients with Lung Cancer

— Observational United States

Lung Cancer

Recruiting NCT06470607

The Lymphocytic Infiltrate of Lung Tumors.

— Observational Italy

Lung Cancer · Immune System

Recruiting NCT06626243

Analysis of RATS, VATS and Open Lung Resections After Neoadjuvant Chemo-immunotherapy in Patients Performed in Five Referred Centers

— Observational United States, Italy

Non-Small Cell Lung Cancer

Recruiting NCT03029325

Molecular and Genetic Analysis of Lung Cancer

— Observational United States

Lung Cancer

Recruiting NCT06496386

Robotic Assisted Major Lung Resection in Elderly Patients

— Observational Italy

Lung Cancer

Recruiting NCT05758116

Tislelizumab Consolidation Therapy After Radiotherapy or Sequential Chemoradiation in Locally Advanced NSCLC Patients

Phase II Interventional China

Non-small Cell Lung Cancer · Consolidation Immunotherapy · Radiotherapy or Sequential Chemoradiation

Recruiting NCT05992324

A Validation Study to Evaluate the Performance of Caption Health Lung Guidance and Interpretation

No phase Interventional United States

Shortness of Breath

Recruiting NCT06706713

Study of BEBT-109 in Subjects With EGFR Exon 20 Insertion Mutations Non-Small Cell Lung Cancer

Phase II Interventional China

Non-Small Cell Lung Cancer · EGFR Exon 20 Insertion Mutation

Recruiting NCT06702826

Cadonilimab Combined With Stereotactic Radiotherapy as Second-line Treatment for Brain Metastases

Phase II Interventional China

Non Small Cell Lung Cancer · Brain Metastases · Stereotactic Radiation

Recruiting NCT06648317

Radiolabelled Nectin-4 Targeted LMW Probe PET/CT in Patients With Lung Lesions

— Observational China

Lung Cancer, Non-Small Cell · Lung Infection

Recruiting NCT06702228

Precision Diagnosis and Care for Families With Pulmonary Fibrosis in Ireland

— Observational Ireland

Connective Tissue Diseases · Interstitial Lung Disease · Idiopathic Pulmonary Fibrosis

Recruiting NCT05948813

TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases

Phase II Interventional China

NSCLC · EGFR Activating Mutation · Brain Metastases

Recruiting NCT06698965

Efficacy and Safety of First-line Treatment for Extensive-stage Small Cell Lung Cancer Using a Combination Therapy of Trilaciclib, Envafolimab, Etoposide, and Carboplatin

Phase II Interventional China

Lung Cancer, Small Cell

Recruiting NCT06632262

A Phase 2 Clinical Study of ABSK061 and ABSK043

Phase II Interventional China

HER2-Gastric/Gastroesophageal Junction Cancer · Urothelial Carcinoma · Non-Small Cell Lung Cancer

Not yet recruiting NCT06694129

Real-world Observational Study of Targeted Therapy in Patients With Advanced ROS1-positive NSCLC

— Observational —

Non-Small Cell Lung Cancer · ROS1 Gene Rearrangement · Resistance

Recruiting NCT06440746

Efficacy and Safety of Olokizumab in Patients With Progressive Fibrosing Interstitial Lung Diseases

Phase II / Phase III Interventional Russia

Lung Diseases, Interstitial

Recruiting NCT06087692

Efficacy of Video-Based Interactive Game Therapy in Interstitial Lung Patients

No phase Interventional Turkey (Türkiye)

Interstitial Lung Disease

Recruiting NCT05979818

Propranolol Hydrochloride in Combination With Sintilimab and Platinum-based Chemotherapy for Treatment of Advanced Non-small Cell Lung Cancer

Phase I Interventional China

Non Small Cell Lung Cancer · Propranolol

Recruiting NCT04973293

Preoperative Sintilimab Combined With Bevacizumab and Chemotherapy for Resectable Non-Small Cell Lung Cancer

No phase Interventional China

Lung Neoplasm Malignant

Recruiting NCT06573073

Evaluation of Clinical Performance and IVD Test of LifeOS Digital PCR Liquid Biopsy Kits for EGFR T790M Mutation

— Observational Taiwan

Non Small Cell Lung Cancer · EGFR T790M

Recruiting NCT06269211

Neoadjuvant Toripalimab for Clinically Stage II-IIIB Resectable Non-small Cell Lung Cancer with EGFR Mutation and PD-L1 Positive Expression

Phase II Interventional China

Carcinoma, Non-Small-Cell Lung

Recruiting NCT05933876

The Impact of Radiotherapy on Oligometastatic Cancer

— Observational Spain

Metastasis · Metastatic Breast Cancer · Metastatic Prostate Cancer

Not yet recruiting NCT06690541

Real-world Study of Local Therapy Changes During 1L Lorlatinib in Unresectable ALK+ NSCLC

— Observational —

Lung Cancer, Non-Small Cell

Not yet recruiting NCT06690671

A Single-Arm, Phase Ⅰb Study of Golidocitinib Combined With Anti-PD-1 for the Treatment of Previously Treated NSCLC

Phase I / Phase II Interventional China

Lung Cancer, Non-Small Cell

Recruiting NCT04787042

Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

Phase I / Phase II Interventional United States

Cancer · Solid Tumor · Melanoma

Recruiting NCT06690385

DEPRECAP: Lung Cancer Screening Programme by LDCT for Patients With COPD or Emphysema.

— Observational Spain

Lung Cancer · COPD · Emphysema

Recruiting NCT05671887

DREAM: Double Lung Transplant REgistry Aimed for Lung-limited Malignancies

— Observational United States

Lung Cancer · Bilateral Cancer · Lung Transplant

Not yet recruiting NCT06689020

Positive Expiratory Pressure (PEP) and Continuous High-frequency Oscillation (CHFO) on Lung RECRUITment Using Electrical Impedance Tomography (EIT) - The PEP-RECRUIT Study

— Observational Italy

Recruitment · Respiratory Failure

Not yet recruiting NCT06688656

Neoadjuvant Chemotherapy Sequentially Combined with Sintilimab in Resectable EGFR-Mutant NSCLC

Phase II Interventional China

Lung Cancer

Enrolling by invitation NCT06610240

Perioperative Treatment Outcomes of Early NSCLC

— Observational China

NSCLC

Recruiting NCT06426628

Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier

— Observational United States, Puerto Rico

Pulmonary Nodule, Solitary · Lung Cancer

Not yet recruiting NCT06685458

Constructing a Predictive Model for Differentiating Between Benign and Malignant Solid Pulmonary Nodules Based on Clinical and Imaging Features.

— Observational —

Lung Cancer · Solid Pulmonary Nodules · Pulmonary Nodules

Recruiting NCT06589778

A Study of SHR-A2102 in Combination With Adebrelimab and SHR-8068 in Subjects With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Phase I / Phase II Interventional China

Non-Small Cell Lung Cancer

Not yet recruiting NCT06684873

A Multicenter, Single-arm, Open-label Study Evaluating the Safety and Efficacy of AK112 Combined With Chemotherapy as First-line Treatment for Non-squamous NSCLC Patients With BRAIN Metastases and Negative Driver Genes (IVO BRAIN)

Phase II Interventional China

NSCLC · Brain Metastasases

Recruiting NCT06604689

AI-guided Prognostication and Cranial Radiotherapy Optimization in EGFR-TKI-treated Non-small Cell Lung Cancer Patients With Baseline Brain Metastases

— Observational China

NSCLC (Advanced Non-small Cell Lung Cancer) · Brain Metastasases

Not yet recruiting NCT06685653

Personalized Neoantigen MRNA Vaccine Combined with Adebrelimab in Non-Small Cell Lung Cancer Patients

Early Phase I Interventional —

NSCLC

Not yet recruiting NCT06682884

Lorlatinib as Neoadjuvant Treatment in Stage IB-IIIB ALK-rearranged Non-Small Cell Lung Cancer

Phase II Interventional —

Neoadjuvant Non-Small Cell Lung Cancer

Not yet recruiting NCT06683703

Utidelone Injection Combined with Bevacizumab Injection for Non-small Cell Lung Cancer Patients with Brain Metastases

Phase II Interventional —

Non-small Cell Lung Cancer Patients with Brain Metastases

Recruiting NCT06388031

ICI Rechallenge for Advanced NSCLC With Long-Term Response to First-Line ICI

Phase II Interventional China

Non-small Cell Lung Cancer

Recruiting NCT04854213

PRELUDE-1 (Prospective Evaluation of Radiotherapy-induced Biologic Effects in Colorectal Cancer Oligometastatic Patients with LUng-limited Disease: Evolution of Cancer Genetics and Regulatory Immune Cells)

No phase Interventional Italy

Colorectal Cancer Metastatic

Not yet recruiting NCT06678035

Use of Simplified Lung Ultrasound Score for Predicting ICU Outcomes in Patients With Acute Respiratory Failure

— Observational —

Pneumnia · Chest Infection · Critically-ill Patients Admitted to the ICU for Acute Respitatory Failure, Regardless the Aetilogy

Not yet recruiting NCT06679712

Transbroncheal Novel PDT Peripheral Lung Tumor Ablation With 5-ALA

No phase Interventional Taiwan

Lung Cancer - Non Small Cell · Lung Metastases From Any Primary

Recruiting NCT06679777

Swedish CArdioPulmonary bioImage Study 2

— Observational Sweden

Cardiovascular Diseases · Lung Diseases

Not yet recruiting NCT06652529

Phase 1 Dose Escalation and Expansion to Evaluate AROG4-01 in Patients With Advanced Solid Tumors

Phase I Interventional —

Solid Tumors (Phase 1) · Mesothelioma · Colorectal Carcinoma

Recruiting NCT06674343

Furmonertinib 160mg as First-line Treatment in Locally Advanced or Metastatic NSCLC With EGFR Classical Mutations

Phase III Interventional China

Advanced or Metastatic Non-small Cell Lung Cancer

Recruiting NCT06674148

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Qifangfeixian Granules in the Treatment of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD)

Phase II / Phase III Interventional China

Interstitial Lung Disease · Qifangfeixian Granules

Not yet recruiting NCT06672133

Adebrelimab Combined with Chemotherapy and Thoracic Radiotherapy for First-line Treatment of ES-SCLC

Phase III Interventional —

Extensive Stage Lung Small Cell Carcinoma

Recruiting NCT05435248

Phase 1/2 Study of HS-10375 in Patients with Advanced or Metastatic Non-Small-Cell Lung Cancer(NSCLC)

Phase I / Phase II Interventional China

Advanced or Metastatic NSCLC

Recruiting NCT06178510

I-ASV in Cardiac Surgery

No phase Interventional Austria

Ventilator Lung