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Идёт набор NCT07668596

Independent and Combined Effects of Short-term Sulforaphane Supplementation and Exercise on Immunometabolism in Healthy Adults

Без фазы С лечением Immunometabolism Mitochondrial Function, Bioenergetics Inflammation

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Sulforaphane-rich Broccoli Sprout Extract, High Intensity Interval Treadmill Running.
Кому может быть актуально
Состояния в реестре: Immunometabolism, Mitochondrial Function, Bioenergetics, Inflammation. Базовые параметры: 19 лет — 35 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Канада
Следующий шаг
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Официальное название

Independent and Combined Effects of Short-term Sulforaphane Supplementation and Exercise on Immunometabolism in Healthy Adults: A Randomized Crossover Study

Обзор

The study consist of 3 interventional periods which will be completed by each consenting participant in a randomized, crossover fashion. The interventional periods will be separated by a minimum 1 week washout period. One of the interventions consists of 4 days of daily supplementation with the commercially available broccoli sprout extract capsules (BrocElite). Another intervention will consist of 4 days of daily supervised treadmill running. The exercise protocol consists of 4 minutes of high-intensity running running followed by a 3 minute recovery period, repeated for a total of 4 repetitions. The last intervention combines the above two and consists of 4 days of daily supplementation and daily supervised exercise training. Before and after each intervention, basic anthropometrics (weight, heart rate, and blood pressure) will be recorded, and a venous blood sample will be collected. Blood samples will be analyzed for metabolic and inflammatory markers. Participants will be asked to refrain from structured exercise, alcohol consumption, and broccoli consumption during each of the experimental periods. Before any testing, willing participants will provide informed consent, and fill out a few demographic, and lifestyle questionnaires. The study will be conducted at the University of British Columbia in Kelowna, BC, Canada.

Вмешательства

  • Пищевая добавка Sulforaphane-rich Broccoli Sprout Extract
    Broc Elite Plus stabilized sulforaphane capsules from Mara Labs
  • Другое High Intensity Interval Treadmill Running
    4 cycles of: 4 minutes of intense treadmill running (85-95% HR max) followed by 3 minutes of slow, easy running.

Первичные конечные точки

  • Change in peripheral blood mononuclear cell oxygen consumption rate [Срок оценки: 0-4 days]
Вторичные конечные точки (12)
  • TNF-alpha secretion from LPS-stimulated whole blood [Срок оценки: 0-4 days]
  • Change in percentage of classical monocytes before and after the 6-week intervention [Срок оценки: 0-4 days]
  • Change in percentage of intermediate monocytes before and after the 4-day intervention [Срок оценки: 0-4 days]
  • Change in percentage of non-classical monocytes before and after the 4-day intervention [Срок оценки: 0-4 days]
  • Change in TLR-4 expression on classical monocytes before and after the 4-day intervention [Срок оценки: 0-4 days]
  • Change in TLR-4 expression on intermediate monocytes before and after the 4-day intervention [Срок оценки: 0-4 days]
  • Change in TLR-4 expression on non-classical monocytes before and after the 4-day intervention [Срок оценки: 0-4 days]
  • Change in white blood cell counts before and after the 4-day intervention [Срок оценки: 0-4 days]
  • TNF-alpha secretion from PolyIC-stimulated whole blood [Срок оценки: 0-4 days]
  • Change in peripheral blood mononuclear cell extracellular acidification rate before and after the 4-day period [Срок оценки: 0-4 days]
  • Change in PBMC mitotracker green staining before and after the 4-day period [Срок оценки: 0-4 days]
  • Change in PBMC mitoSOX red staining before and after the 4-day period [Срок оценки: 0-4 days]

Критерии участия

Критерии включения

  • aged between 19 and 35 years
  • not a current smoker
  • physically active based on the Canadian Physical Activity Guidelines (150 minutes of weekly physical activity)

Критерии исключения

  • a history of cardiometabolic diseases or respiratory diseases (e.g., chronic obstructive pulmonary disease, asthma, diabetes, coronary artery disease)
  • currently following a ketogenic diet
  • body mass index (BMI) over 30 kg/m2
  • unable to read or communicate in English
  • having received a vaccination or experienced an upper respiratory tract infection in the last 4 weeks
  • having donated more than 0.5 L of blood within the last 4 weeks
  • currently pregnant
  • have contraindications to high intensity exercise (assessed using the CSEP Get Active Questionnaire)

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение
Рандомизированное
Модель
Перекрёстный дизайн
Маскирование
Открытое
Основная цель
Фундаментальное исследование

Центры проведения

Канада · 1 центр
  • Reichwald Health Sciences Centre — Kelowna

Идентификаторы

NCT: NCT07668596 · H25-03273

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗