Effect of Early Gait Training on Knee Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction

Обзор

A randomized controlled clinical study was conducted to elucidate the relationship between the lower extremity biomechanics of patients undergoing early gait training after ACLR surgery.The relationship between the biochemical characteristics of cartilage and the biomechanical risk index were proposed to providing exercise guidance and training for ACLR people and it is suggested that it can prevent and reduce the risk of cartilage degeneration early after operation.

Подробное описание

In this randomized controlled clinical study, patients with primary unilateral ACL rupture were included. In addition to standardized rehabilitation training content, gait training intervention under weight loss was added to the subjects in the early postoperative period. The control group only received standardized rehabilitation training. Based on motion testing and dynamic analysis, the influence of early postoperative gait training on postoperative gait biomechanical characteristics was explored. And the influence of early cartilage health status; Based on functional MRI, the effects of early postoperative gait training on biochemical parameters of knee tibiofemoral and patellofemoral cartilage were investigated.

Вмешательства

• Другое lower-body positive-pressure
  By increasing the chamber in the lower body around Pressure acts as a counterweight to gravity

Первичные конечные точки

• Gait biomechanical data [Срок оценки: from 3 months to 2 years]
• Gait biomechanical data [Срок оценки: from 3 months to 2 years]
• Gait biomechanical data [Срок оценки: from 3 months to 2 years]
• Gait biomechanical data [Срок оценки: from 3 months to 2 years]
• Gait biomechanical data [Срок оценки: from 3 months to 2 years]
• Biochemical characteristics of knee cartilage [Срок оценки: from 3 months to 2 years]
• Biochemical characteristics of knee cartilage [Срок оценки: from 3 months to 2 years]

Критерии участия

Критерии включения

• Patients with ACL rupture were diagnosed by MRI;
• Unilateral ACL rupture for the first time should be performed in our hospital (Department of Sports Medicine, Peking University Third Hospital)The art of reconstruction;
• Normal BMI range: 18.5-23.9 kg/m2;
• Within 6 months from the trauma;
• The affected knee joint has passed the acute stage, no obvious redness, pain,inflammation, and limited joint motion,basically restore joint motion.

Критерии исключения

• BMI<18.5 kg/m2 or BMI≥24 kg/m2);
• There is a history of contralateral lower limb musculoskeletal system injury and surgery;
• ACL injury time > 6 months;
• Outerbridge damage rating Ⅲ and Ⅳ;
• Patients with meniscal tears who are expected to undergo meniscal suture surgery at the time of ACLR surgery;
• Serious injury to the posterior cruciate ligament, medial collateral ligament, or lateral collateral ligament;
• There is metabolic syndrome (obesity, dyslipidemia, diabetes, etc.), which will involve articular cartilage Epidemic diseases, serious cardiovascular and cerebrovascular diseases, etc.;
• Those who do not want to accept this treatment

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Профилактика

Центры проведения

Китай · 1 центр

• Peking University Third Hospital — Пекин

Публикации

• Dang R, Lu Y, Zhou Z, Zhou Z, Cui N, Yu Y, Zhang S, Ao Y, Huang H, Wang J, Ren S. Biomechanical mechanisms of early gait training on knee cartilage degeneration after anterior cruciate ligament reconstruction: a study protocol. Front Sports Act Living. 2026 Jun 24;8:1833258. doi: 10.3389/fspor.2026.1833258. eCollection 2026. PMID 42421839

Идентификаторы

NCT: NCT06368544 · M2023816

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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