Effect of Early Gait Training on Knee Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: lower-body positive-pressure.
- Who it may be relevant to
- Registry conditions: Anterior Cruciate Ligament Injuries, Cartilage Degeneration. Basic parameters: 18 years — 40 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
A randomized controlled clinical study was conducted to elucidate the relationship between the lower extremity biomechanics of patients undergoing early gait training after ACLR surgery.The relationship between the biochemical characteristics of cartilage and the biomechanical risk index were proposed to providing exercise guidance and training for ACLR people and it is suggested that it can prevent and reduce the risk of cartilage degeneration early after operation.
Detailed description
In this randomized controlled clinical study, patients with primary unilateral ACL rupture were included. In addition to standardized rehabilitation training content, gait training intervention under weight loss was added to the subjects in the early postoperative period. The control group only received standardized rehabilitation training. Based on motion testing and dynamic analysis, the influence of early postoperative gait training on postoperative gait biomechanical characteristics was explored. And the influence of early cartilage health status; Based on functional MRI, the effects of early postoperative gait training on biochemical parameters of knee tibiofemoral and patellofemoral cartilage were investigated.
Interventions
- Other lower-body positive-pressure
By increasing the chamber in the lower body around Pressure acts as a counterweight to gravity
Primary outcome measures
- Gait biomechanical data [Time frame: from 3 months to 2 years]
- Gait biomechanical data [Time frame: from 3 months to 2 years]
- Gait biomechanical data [Time frame: from 3 months to 2 years]
- Gait biomechanical data [Time frame: from 3 months to 2 years]
- Gait biomechanical data [Time frame: from 3 months to 2 years]
- Biochemical characteristics of knee cartilage [Time frame: from 3 months to 2 years]
- Biochemical characteristics of knee cartilage [Time frame: from 3 months to 2 years]
Eligibility criteria
Inclusion criteria
- Patients with ACL rupture were diagnosed by MRI;
- Unilateral ACL rupture for the first time should be performed in our hospital (Department of Sports Medicine, Peking University Third Hospital)The art of reconstruction;
- Normal BMI range: 18.5-23.9 kg/m2;
- Within 6 months from the trauma;
- The affected knee joint has passed the acute stage, no obvious redness, pain,inflammation, and limited joint motion,basically restore joint motion.
Exclusion criteria
- BMI<18.5 kg/m2 or BMI≥24 kg/m2);
- There is a history of contralateral lower limb musculoskeletal system injury and surgery;
- ACL injury time > 6 months;
- Outerbridge damage rating Ⅲ and Ⅳ;
- Patients with meniscal tears who are expected to undergo meniscal suture surgery at the time of ACLR surgery;
- Serious injury to the posterior cruciate ligament, medial collateral ligament, or lateral collateral ligament;
- There is metabolic syndrome (obesity, dyslipidemia, diabetes, etc.), which will involve articular cartilage Epidemic diseases, serious cardiovascular and cerebrovascular diseases, etc.;
- Those who do not want to accept this treatment
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Prevention
Study locations
China · 1 center
- Peking University Third Hospital — Beijing
Publications
- Dang R, Lu Y, Zhou Z, Zhou Z, Cui N, Yu Y, Zhang S, Ao Y, Huang H, Wang J, Ren S. Biomechanical mechanisms of early gait training on knee cartilage degeneration after anterior cruciate ligament reconstruction: a study protocol. Front Sports Act Living. 2026 Jun 24;8:1833258. doi: 10.3389/fspor.2026.1833258. eCollection 2026. PMID 42421839
Identifiers
NCT: NCT06368544 · M2023816