Standardising and Simplifying the Global Leadership Initiative on Malnutrition (GLIM) for Its More General Application

Обзор

This observational study of aims to test whether and how the results of GLIM change when using different approaches and methods to carry out its components.

Подробное описание

The main questions the study aims to answer are:

* What is the most effective pre-GLIM screening approach? * Which of the simple, globally accessible muscle mass measurement methods works the best in the context of GLIM? * How does using simpler approaches to screening and muscle mass measurement affect the performance of GLIM in detecting Subjective Global Assessment (SGA) defined malnutrition and 1-year mortality?

Participants will be/have:

* asked questions about their recent food intake and possible non-volitional weight loss * assessed for malnutrition with SGA * weighed, and their height will be measured (if not already recorded) * their muscle mass measured with a measuring tape (mid-upper arm circumference and calf circumference) and bioelectrical impedance * their muscle function measured using hand grip strength * have their patient records looked at to extract their weight and height data (if present), diagnoses, routine blood test results, abdominal computed tomography (CT) scan (if present), dual-energy x-ray absorptiometry (DEXA) scan (if present), 1-year mortality and personal identification code for documentation (the latter will be deleted when the study period is over).

Вмешательства

• Диагностический тест Nutrition screening and assessment
  The patient is interviewed for changes in body weight in the last six months and food intake in the last two weeks. The investigator evaluates the patient's diet, symptoms related to their nutritional status, and functional capacity according to the Subjective Global Assessment (SGA). The SGA tool itself is completed by the researcher. Height and weight of the patient are measured, if not yet recorded, and BMI is calculated. The patient's muscle mass is measured using mid-upper arm circumfere

Первичные конечные точки

• Subjective Global Assessment (SGA) defined malnutrition [Срок оценки: baseline, pre-intervention/procedure/surgery]
• One-year mortality [Срок оценки: through study completion, an average of 1 year]
• Computed tomography (CT) defined muscle mass [Срок оценки: baseline, pre-intervention/procedure/surgery]
• DEXA defined muscle mass [Срок оценки: baseline, pre-intervention/procedure/surgery]

Вторичные конечные точки (1)

• Bioelectrical impedance (BIA) defined muscle mass [Срок оценки: baseline, pre-intervention/procedure/surgery]

Критерии участия

Критерии включения

• Age of 18+ years
• Able and willing to sign the consent form
• Inpatients of the Tartu University Hospital
• Admitted within 72 hours before enrolment

Критерии исключения

• Age of <18 years
• Inability or refusal to sign the consent form
• Pregnant or lactating women
• More than 72 hours passed since admission
• Patients isolating with an infection

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Эстония · 1 центр

• Tartu Ülikooli Kliinikum — Tartu

Идентификаторы

NCT: NCT06164925 · 23092

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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