Standardising and Simplifying the Global Leadership Initiative on Malnutrition (GLIM) for Its More General Application
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Nutrition screening and assessment.
- Who it may be relevant to
- Registry conditions: Malnutrition. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Estonia
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This observational study of aims to test whether and how the results of GLIM change when using different approaches and methods to carry out its components.
Detailed description
The main questions the study aims to answer are:
* What is the most effective pre-GLIM screening approach? * Which of the simple, globally accessible muscle mass measurement methods works the best in the context of GLIM? * How does using simpler approaches to screening and muscle mass measurement affect the performance of GLIM in detecting Subjective Global Assessment (SGA) defined malnutrition and 1-year mortality?
Participants will be/have:
* asked questions about their recent food intake and possible non-volitional weight loss * assessed for malnutrition with SGA * weighed, and their height will be measured (if not already recorded) * their muscle mass measured with a measuring tape (mid-upper arm circumference and calf circumference) and bioelectrical impedance * their muscle function measured using hand grip strength * have their patient records looked at to extract their weight and height data (if present), diagnoses, routine blood test results, abdominal computed tomography (CT) scan (if present), dual-energy x-ray absorptiometry (DEXA) scan (if present), 1-year mortality and personal identification code for documentation (the latter will be deleted when the study period is over).
Interventions
- Diagnostic test Nutrition screening and assessment
The patient is interviewed for changes in body weight in the last six months and food intake in the last two weeks. The investigator evaluates the patient's diet, symptoms related to their nutritional status, and functional capacity according to the Subjective Global Assessment (SGA). The SGA tool itself is completed by the researcher. Height and weight of the patient are measured, if not yet recorded, and BMI is calculated. The patient's muscle mass is measured using mid-upper arm circumfere
Primary outcome measures
- Subjective Global Assessment (SGA) defined malnutrition [Time frame: baseline, pre-intervention/procedure/surgery]
- One-year mortality [Time frame: through study completion, an average of 1 year]
- Computed tomography (CT) defined muscle mass [Time frame: baseline, pre-intervention/procedure/surgery]
- DEXA defined muscle mass [Time frame: baseline, pre-intervention/procedure/surgery]
Secondary outcome measures (1)
- Bioelectrical impedance (BIA) defined muscle mass [Time frame: baseline, pre-intervention/procedure/surgery]
Eligibility criteria
Inclusion criteria
- Age of 18+ years
- Able and willing to sign the consent form
- Inpatients of the Tartu University Hospital
- Admitted within 72 hours before enrolment
Exclusion criteria
- Age of <18 years
- Inability or refusal to sign the consent form
- Pregnant or lactating women
- More than 72 hours passed since admission
- Patients isolating with an infection
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Estonia · 1 center
- Tartu Ülikooli Kliinikum — Tartu
Identifiers
NCT: NCT06164925 · 23092