Fresh Gas Flow and Lung Ultrasonography in Laparoscopic Cholecystectomy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Low Fresh Gas Flow (0.5 L/min), High Fresh Gas Flow (4 L/min).
- Who it may be relevant to
- Registry conditions: Postoperative Atelectasis, Pulmonary Atelectasis. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Evaluation of the Effects of Fresh Gas Flow Differences on the Lungs Using Ultrasonography in Laparoscopic Cholecystectomy Surgeries
Overview
This prospective randomized clinical trial aims to evaluate the effects of different fresh gas flow rates on postoperative pulmonary aeration using lung ultrasonography in patients undergoing elective laparoscopic cholecystectomy. Patients will be randomly assigned to receive either low-flow anesthesia (0.5 L/min) or high-flow anesthesia (4 L/min) during maintenance of general anesthesia. The primary objective is to compare postoperative lung ultrasound scores and the incidence of atelectasis between the two groups.
Detailed description
Pulmonary atelectasis is one of the most common postoperative pulmonary complications following general anesthesia. Fresh gas flow is an important component of inhalational anesthesia and may influence airway humidity, gas exchange, respiratory mechanics, and pulmonary physiology. Although low-flow anesthesia has recognized economic, environmental, and physiological advantages, the effect of different fresh gas flow rates on postoperative lung aeration has not been adequately investigated.
This prospective, randomized, parallel-group clinical trial will be conducted at Adıyaman University Training and Research Hospital. Adult patients scheduled for elective laparoscopic cholecystectomy under general anesthesia will be randomly allocated to either a low-flow group (0.5 L/min) or a high-flow group (4 L/min) after an initial fresh gas flow of 4 L/min for 8 minutes following endotracheal intubation. Standardized anesthesia management will be applied to all participants.
Postoperative lung ultrasonography will be performed 30 minutes after extubation in the post-anesthesia care unit. Lung Ultrasound Score (LUS) and the incidence of postoperative atelectasis will be compared between the study groups. The findings are expected to provide evidence regarding the effects of different fresh gas flow strategies on postoperative pulmonary outcomes and may contribute to optimizing intraoperative anesthesia management.
Interventions
- Procedure Low Fresh Gas Flow (0.5 L/min)
General anesthesia will be maintained using a fresh gas flow rate of 0.5 L/min after an initial fresh gas flow of 4 L/min for 8 minutes following endotracheal intubation. - Procedure High Fresh Gas Flow (4 L/min)
General anesthesia will be maintained using a fresh gas flow rate of 4 L/min after an initial fresh gas flow of 4 L/min for 8 minutes following endotracheal intubation.
Primary outcome measures
- Postoperative Lung Ultrasound Score [Time frame: 30 minutes after extubation]
Secondary outcome measures (5)
- Incidence of postoperative atelectasis [Time frame: 30 minutes after extubation]
- Peripheral oxygen saturation (SpO₂) [Time frame: During surgery]
- Mean arterial pressure [Time frame: During surgery]
- Heart rate [Time frame: During surgery]
- Peak airway pressure [Time frame: Throughout the intraoperative period]
Eligibility criteria
Inclusion criteria
- Adults aged 18 years or older.
- American Society of Anesthesiologists (ASA) physical status I-II.
- Scheduled for elective laparoscopic cholecystectomy under general anesthesia.
- Able and willing to provide written informed consent.
Exclusion criteria
- Refusal to participate in the study.
- History of chronic respiratory disease, including severe asthma, chronic obstructive pulmonary disease (COPD), or bronchiolitis.
- History of alcohol or substance abuse.
- Intraoperative airway or respiratory complications during endotracheal intubation or surgery.
- Life-threatening postoperative complications.
- Patients with ASA physical status III or higher.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Turkey (Türkiye) · 1 center
- Adıyaman Training and Research Hospital — Adıyaman
Identifiers
NCT: NCT07753278 · AH-AR-MD-01