RESTORE-BLADDER (REgistry on STrategies for Organ pREservation in Muscle-invasive BLADDER Cancer)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: None. Registry..
- Who it may be relevant to
- Registry conditions: Muscle Invasive Bladder Cancer (MIBC). Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Removal of the urinary bladder (radical cystectomy) is a major surgical procedure that can have a permanent impact on a patient's quality of life. Consequently, some patients, despite having received comprehensive counseling and completing systemic therapy, decide against subsequent surgery or alternative radiotherapy. Recent scientific studies suggest that, for selected patients, an attempt at bladder preservation may be a medically justifiable option. However, it remains unclear which patients are truly suitable candidates for bladder-preserving management and which are not. The aim of this registry is therefore to collect and analyze clinical data from this specific patient population.
Interventions
- Other None. Registry.
None. Registry.
Primary outcome measures
- 2 year MFS [Time frame: 2 Years]
Eligibility criteria
Inclusion criteria
- Patients aged >= 18 years, capable of providing informed consent
- Histologically confirmed muscle-invasive urothelial carcinoma of the urinary bladder
- Received perioperative systemic therapy in accordance with current guidelines and subsequently decline cystectomy or radiotherapy
Exclusion criteria
- Age < 18 years
- Lack of capacity to provide informed consent
- No histological confirmed muscle-invasive urothelial carcinoma
- No prior preoperative systemic therapy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07744958 · 24072026