Artificial Intelligence-guided Precision Treatment of High-grade Serous Ovarian Carcinoma
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: No Intervention: Observational Cohort.
- Who it may be relevant to
- Registry conditions: High-grade Serous Ovarian Carcinoma (HGSOC). Basic parameters: 18 years — 80 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Personalized Precision Diagnosis and Treatment of High-grade Serous Ovarian Carcinoma During the Perioperative Period Assisted by Multi-omics and Artificial Intelligence Models, and Research on the Heterogeneity of Immune Microenvironment
Overview
The subjects of this study are patients with high-grade serous ovarian cancer who have undergone surgical resection. The aim is to construct an artificial intelligence model for predicting postoperative recurrence, metastasis and overall survival of patients based on multimodal data such as surgical pathological images (HE images and IHC images of immune microenvironment-related markers), preoperative baseline imaging data and detailed clinical information of patients. In addition, multi-omics sequencing analysis will be used to deeply explore the heterogeneity of the tumor microenvironment, with the expectation of quantifying the postoperative recurrence risk of patients with high-grade serous ovarian cancer and providing new ideas for the precise diagnosis and treatment of patients with high-grade serous ovarian cancer.
Interventions
- Other No Intervention: Observational Cohort
This study is an retrospective observational study. There will be no interventions on the participants.
Primary outcome measures
- Disease-free survival [Time frame: through study completion, an average of 1 year]
Eligibility criteria
Inclusion criteria
- Histologically confirmed high-grade serous ovarian carcinoma using resection specimens.
- Well-preserved surgical paraffin-embedded tumor specimens.
- Complete clinical information and survival follow-up data.
Exclusion criteria
- Received preoperative neoadjuvant treatment.
- Poor preservation of surgical paraffin specimens.
- Incomplete clinical information and survival follow-up data.
- With concurrent malignancies other than high-grade serous ovarian carcinoma.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07721675 · QYFYEC2025-365