EFFECT OF PLATELET CONCENTRATE TRANSFUSION ON MICROCIRCULATORY ENDOTHELIAL FUNCTION IN INTENSIVE CARE UNIT
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Thrombocytopenia, Prophylactic Platelet Transfusion, Platelet Transfusion, Endothelial Function. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
EFFECT OF PLATELET CONCENTRATE TRANSFUSION ON MICROCIRCULATORY ENDOTHELIAL FUNCTION IN INTENSIVE CARE UNIT.
Overview
This study aims to investigate the impact of platelet concentrate (PC) transfusions on endothelial function and the systemic inflammatory response in thrombopenic patients admitted to intensive care who require prophylactic platelet transfusions. Endothelial function will be measured using a laser Doppler device coupled with an acetylcholine iontophoresis system that is applied to the skin.
Detailed description
This is a single-centre, non-randomised, non-interventional human research study (RIPH3) investigating the impact of platelet transfusion on endothelial function, endothelial biomarkers, systemic inflammation, oxidative stress and peripheral tissue perfusion. Patients will be recruited during their stay in intensive care, after receiving information and providing their consent (non opposition). Platelet transfusion will be prescribed as part of their treatment. Before the transfusion, at the end of the transfusion and one hour afterwards, a clinical examination will be performed, along with an assessment of tissue perfusion and microcirculatory blood flow measurements using a Doppler laser coupled with iontophoresis. Blood samples will be taken before the transfusion and one hour after its completion to assess the systemic inflammatory response. Participation in this research study will take a maximum of four hours. No specific follow-up is planned for patients included in the study.
Primary outcome measures
- Assessing the effects of platelet transfusion on endothelial function in the microcirculation. Endothelial function will be measured using a Doppler laser coupled with an acetylcholine iontophoresis system applied to the skin. [Time frame: before transfusion, right after transfusion and 1 hour after transfusion]
Secondary outcome measures (7)
- Endothelial biomarker levels [Time frame: before transfusion and 1 hour after transfusion]
- Systemic inflammatory biomarker levels [Time frame: before transfusion and 1 hour after transfusion]
- Oxidative stress [Time frame: before transfusion and 1 hour after transfusion]
- Peripheral tissue perfusion [Time frame: before transfusion, right after transfusion and 1 hour after transfusion]
- Peripheral tissue perfusion [Time frame: before transfusion, right after transfusion and 1 hour after transfusion]
- Skin blood flow [Time frame: before transfusion, right after transfusion and 1 hour after transfusion]
- Urine output [Time frame: before transfusion, right after transfusion and 1 hour after transfusion]
Eligibility criteria
Inclusion criteria
- Adult patient ≥ 18 years of age
- Admitted to intensive care
- Requires prophylactic platelet transfusion for thrombocytopenia
- Enrolled in a social security program
- No objection to participating in the study
Exclusion criteria
- Recent platelet or red blood cell transfusion (< 24 hours)
- Need for urgent red blood cell transfusion due to active bleeding
- Patient under guardianship or conservatorship
- Significant peripheral edema
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- Medical Intensive Care Unit, Saint-Antoine Hospital, AP-HP, Paris, France — Paris
Identifiers
NCT: NCT07682246 · APHP260009 · IDRCB 2026-A00031-50