Tissue Perfusion Pressure for Predicting Fluid Responsiveness in Patients With Shock
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: When the attending physician determines that fluid resuscitation is clinically indicated: Patients will remain in the supine position. Crystalloid solution will be administered intravenously via centr.
- Who it may be relevant to
- Registry conditions: Shock. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Tissue Perfusion Pressure for Predicting Fluid Responsiveness in Patients With Shock: A Prospective Observational Study
Overview
This prospective observational study aims to evaluate the ability of tissue perfusion pressure (TPP) to predict fluid responsiveness in critically ill patients with shock and tissue hypoperfusion. Eligible patients requiring fluid resuscitation will undergo a standardized fluid challenge test. Hemodynamic parameters, including cardiac output and TPP, will be recorded before and after fluid administration. Fluid responsiveness will be defined according to the change in cardiac output following fluid loading. The study will assess the correlation between changes in TPP and cardiac output and evaluate the diagnostic performance of TPP for predicting fluid responsiveness. The results may support the use of TPP as a practical and physiologically relevant parameter for individualized fluid management in patients with shock.
Interventions
- Behavioral When the attending physician determines that fluid resuscitation is clinically indicated: Patients will remain in the supine position. Crystalloid solution will be administered intravenously via centr
Primary outcome measures
- Δ Cardiac output [Time frame: Periprocedural]
- Δ Tissue perfusion pressure [Time frame: Periprocedural]
Eligibility criteria
Inclusion criteria
- Age ≥18 years
- Admitted to the Intensive Care Unit (ICU)
- Diagnosed with shock and evidence of tissue hypoperfusion
- Judged by the treating physician to require fluid resuscitation
- Receiving invasive hemodynamic monitoring
- Written informed consent obtained from the patient or legally authorized representative
Exclusion criteria
- Pregnancy
- Immediate requirement for extracorporeal life support, including: VV-ECMO, VA-ECMO, Ventricular assist devices
- Expected survival less than 72 hours
- Absence of invasive arterial pressure monitoring or arterial waveform availability <25%
- Any condition deemed unsuitable for study participation by the investigator.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07670390 · 2025ZDSYLL481-P01