Bone Cancer Surgery Prospective Database
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Bone cancer surgery.
- Who it may be relevant to
- Registry conditions: Bone Cancer Surgery. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Bone Cancer Surgery Prospective Database on Perioperative Characteristics and Postoperative Complications
Overview
According to the Global Burden of Disease Report, the number of cancer patients worldwide is increasing year by year. In 2023, there were a total of 18.5 million newly confirmed cases of malignant tumors worldwide, and it is expected to grow to 30.5 million cases by 2050. Among them, the number of new cases of malignant tumors of bone and articular cartilage increased by 86.4% from 1990 to 2023. Meanwhile, bone is a particularly common site for tumor metastasis, and almost half of cancer patients are at risk of developing bone metastasis. Surgical resection is the main treatment method for both primary and secondary bone cancer. For patients with bone cancer, the main goal of surgical treatment is to maintain the patient's function and mobility by relieving pain, preventing impending fractures and/or nerve compression, or stabilizing pathological fractures. Surgery for bone cancer often requires extensive exploration, osteotomy, and prosthetic reconstruction, resulting in significant surgical trauma. The incidence of postoperative complications remains high. The occurrence of postoperative complications can increase patient pain, prolong hospitalization time, increase medical costs, and even endanger life. Therefore, reduction of complications and optimizing perioperative management are key issues that urgently need to be addressed in clinical practice.
Detailed description
At present, there is a lack of high-quality evidence-based measures for perioperative management of bone cancer. Previous studies have mainly been retrospective, with common issues such as missing variables, small sample sizes, and single disease types, making it difficult to systematically reveal perioperative pathophysiological patterns and provide reliable evidence for clinical management. Therefore, high-quality prospective studies are urgently needed.
Therefore, this study intends to conduct a prospective cohort study of patients undergoing surgery for bone cancer, establish a perioperative database, clarify the incidence of complications, explore the factors related to perioperative complications, and provide evidence-based support for improving perioperative management and patient prognosis.
Interventions
- Procedure Bone cancer surgery
patients receive surgery based on the doctor's discretion and the consideration of the patients and their family
Primary outcome measures
- Complication [Time frame: hospital discharge, an average of 10 days]
Secondary outcome measures (8)
- The rate of perioperative transfusion of allogeneic blood products [Time frame: hospital discharge, an average of 10 days]
- Wound drainage volume [Time frame: hospital discharge, an average of 10 days]
- The coagulation function tests during the perioperative period [Time frame: hospital discharge, an average of 10 days]
- Hemoglobin levels [Time frame: hospital discharge, an average of 10 days]
- 6-month mortality [Time frame: 6 months]
- 1-year mortality [Time frame: 1 year]
- 2-year mortality [Time frame: 2 years]
- 3-year mortality [Time frame: 3 years]
Eligibility criteria
Inclusion criteria
- Clinical diagnosis of bone cancer
- Scheduled to undergo elective bone cancer resection surgery
Exclusion criteria
- Unable to comply with follow-up
- declined participation in the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- The Second Affiliated Hospital of Zhejiang University anesthesiology department — Hangzhou
Identifiers
NCT: NCT07669103 · 2026 0873