Bone Cancer Surgery Prospective Database

Официальное название

Bone Cancer Surgery Prospective Database on Perioperative Characteristics and Postoperative Complications

Обзор

According to the Global Burden of Disease Report, the number of cancer patients worldwide is increasing year by year. In 2023, there were a total of 18.5 million newly confirmed cases of malignant tumors worldwide, and it is expected to grow to 30.5 million cases by 2050. Among them, the number of new cases of malignant tumors of bone and articular cartilage increased by 86.4% from 1990 to 2023. Meanwhile, bone is a particularly common site for tumor metastasis, and almost half of cancer patients are at risk of developing bone metastasis. Surgical resection is the main treatment method for both primary and secondary bone cancer. For patients with bone cancer, the main goal of surgical treatment is to maintain the patient's function and mobility by relieving pain, preventing impending fractures and/or nerve compression, or stabilizing pathological fractures. Surgery for bone cancer often requires extensive exploration, osteotomy, and prosthetic reconstruction, resulting in significant surgical trauma. The incidence of postoperative complications remains high. The occurrence of postoperative complications can increase patient pain, prolong hospitalization time, increase medical costs, and even endanger life. Therefore, reduction of complications and optimizing perioperative management are key issues that urgently need to be addressed in clinical practice.

Подробное описание

At present, there is a lack of high-quality evidence-based measures for perioperative management of bone cancer. Previous studies have mainly been retrospective, with common issues such as missing variables, small sample sizes, and single disease types, making it difficult to systematically reveal perioperative pathophysiological patterns and provide reliable evidence for clinical management. Therefore, high-quality prospective studies are urgently needed.

Therefore, this study intends to conduct a prospective cohort study of patients undergoing surgery for bone cancer, establish a perioperative database, clarify the incidence of complications, explore the factors related to perioperative complications, and provide evidence-based support for improving perioperative management and patient prognosis.

Вмешательства

• Процедура Bone cancer surgery
  patients receive surgery based on the doctor's discretion and the consideration of the patients and their family

Первичные конечные точки

• Complication [Срок оценки: hospital discharge, an average of 10 days]

Вторичные конечные точки (8)

• The rate of perioperative transfusion of allogeneic blood products [Срок оценки: hospital discharge, an average of 10 days]
• Wound drainage volume [Срок оценки: hospital discharge, an average of 10 days]
• The coagulation function tests during the perioperative period [Срок оценки: hospital discharge, an average of 10 days]
• Hemoglobin levels [Срок оценки: hospital discharge, an average of 10 days]
• 6-month mortality [Срок оценки: 6 months]
• 1-year mortality [Срок оценки: 1 year]
• 2-year mortality [Срок оценки: 2 years]
• 3-year mortality [Срок оценки: 3 years]

Критерии участия

Критерии включения

• Clinical diagnosis of bone cancer
• Scheduled to undergo elective bone cancer resection surgery

Критерии исключения

• Unable to comply with follow-up
• declined participation in the study

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Китай · 1 центр

• The Second Affiliated Hospital of Zhejiang University anesthesiology department — Ханчжоу

Идентификаторы

NCT: NCT07669103 · 2026 0873

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗