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Recruiting NCT07635329

Home-based Vision Rehabilitation Guided by Brain Imaging

No phase Interventional Visual Field Defect Stroke Hemianopia Homonymous Quadrantanopia

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: High-level perceptual learning-based training, Low-level perceptual learning-based training.
Who it may be relevant to
Registry conditions: Visual Field Defect, Stroke, Hemianopia Homonymous, Quadrantanopia. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Behavioral Rehabilitation Through Image-Guided Home-based Training

Overview

The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss. Using a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.

Interventions

  • Behavioral High-level perceptual learning-based training
    Behavioral intervention consisting of repeated computerized visual discrimination tasks targeting higher-order visual processing
  • Behavioral Low-level perceptual learning-based training
    behavioral intervention consisting of repeated computerized visual discrimination tasks targeting low-level visual processing

Primary outcome measures

  • Change in high-level perceptual discrimination performance [Time frame: Week 2-4 or Week 7-9 of the study (depending on the order)]
  • Change in low-level perceptual discrimination performance [Time frame: Week 2-4 or Week 7-9 of the study (depending on the order)]

Eligibility criteria

Inclusion criteria

  • At least 18 years of age.
  • Capable of providing informed consent and complying with study procedures.
  • Unilateral or bilateral focal brain damage causing visual field loss.
  • At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.
  • Eligible for MRI based on standard safety screening.

Exclusion criteria

  • Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.
  • Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.
  • Ocular disease or disorder.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Crossover
Masking
Open label
Primary purpose
Treatment

Study locations

United States · 1 center
  • Georgetown University Medical Center — Washington D.C.

Identifiers

NCT: NCT07635329 · STUDY00010314 · 26CDA1590827

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗