Recruiting NCT05697874
International Rare Brain Tumor Registry
Astroblastoma · BCOR ITD Sarcoma · CNS Sarcoma
CNS tumors
876 trials in this section
Recruiting NCT07173829
A Study to Better Understand the Biological and Molecular Mechanisms Involved in Glioblastoma Recurrence and Progression
Glioblastoma
Not yet recruiting NCT07751744
Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma
Brain Metastases From Solid Tumors · Leptomeningeal Disease · High Grade Glioma (HGG)
Recruiting NCT05432804
Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment
Recurrent Glioblastoma, IDH-Wildtype · Recurrent MGMT-Methylated Glioblastoma
Recruiting NCT07652762
IN10018 in Combination With Dalpiciclib for Progressive Meningiomas
Meningioma · CDK4/6 Inhibitor
Enrolling by invitation NCT06391294
Neuronal and Network Mechanisms of Electrocortical Stimulation
Epilepsy · Brain Tumor Adult
Not yet recruiting NCT07558473
Measuring Brain Changes Following Cognitive Intervention in Pediatric Patients With Brain Tumors
Brain Tumor, Pediatric
Recruiting NCT05099003
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)
Malignant Glioma
Recruiting NCT07326566
Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII
Glioblastoma (GBM) · Newly Diagnosed Glioblastoma · GBM
Recruiting NCT07003542
A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas
Glioblastoma · Brain Tumor
Recruiting NCT07750457
Proton vs. Photon Radiotherapy for Patients With WHO Grade 2-3 Glioma
Glioma
Recruiting NCT05565118
Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression
High Grade Glioma · Glioblastoma
Recruiting NCT04774718
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors
ALK Fusion-positive Solid or CNS Tumors
Recruiting NCT06322602
Ommaya Reservoir Placement at the Time of Biopsy for Longitudinal Biomarker Collection in Patients With Brain Tumors
Brain Neoplasms
Recruiting NCT05708352
A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment
Glioblastoma Multiforme
Recruiting NCT05902169
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM
Glioblastoma · Recurrent Glioblastoma · GBM
Recruiting NCT02523014
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas
Intracranial Meningioma · Recurrent Meningioma · NF2 Gene Mutation
Recruiting NCT03643549
Bortezomib and Temozolomide in Recurrent Grade-4 Glioma Unmethylated MGMT Promoter (BORTEM-17)
Glioblastoma
Recruiting NCT04166409
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma
Low Grade Astrocytoma · Low Grade Glioma · Metastatic Low Grade Astrocytoma
Recruiting NCT07091864
Continuous Glucose Monitoring for the Management of Hyperglycemia in Patients With Glioblastoma
Glioblastoma, IDH-Wildtype · WHO Grade 4 Glioma
Recruiting NCT07110246
Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas
BRAF V600 Mutation · Low-grade Glioma · Low Grade Glioma of Brain
Recruiting NCT00083512
Collection of Blood and Urine Samples in Patients Receiving Radiation Therapy for Glioblastoma Multiforme
Glioblastoma Multiforme
Not yet recruiting NCT07743138
STOMP OUT: A Phase 2 Study To Evaluate The Effects Of Ivonescimab In Patients With Unresectable/Metastatic Adrenocortical Carcinoma (ACC) Or Unresectable Pheochromocytoma/Paraganglioma (PPGL)
Phase II · Ivonescimab · Evaluate
Recruiting NCT06624371
Atovaquone Combined With Radiation in Children With Malignant Brain Tumors
High-grade Glioma · Medulloblastoma · Diffuse Intrinsic Pontine Glioma
Recruiting NCT06816927
Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab
Newly Diagnosed Glioblastoma
Recruiting NCT06860594
Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma
Astrocytoma, IDH-Mutant, Grade 2 · Recurrent Adult Diffuse Hemispheric Glioma, H3 G34-Mutant · Recurrent Adult Diffuse Midline Glioma, H3 K27-Mutant
Recruiting NCT06069726
A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial
Recurrent Glioblastoma
Not yet recruiting NCT07206849
Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)
High Grade Glioma (HGG) of the Brain With BRAF Aberration · High Grade Glioma (III or IV) · Diffuse Intrinsic Pontine Glioma
Not yet recruiting NCT07738601
Patient Reported Outcome Measurement Within the Secured Access to Innovative Medicines for Children With cAncer (SACHA) Study
CNS Tumor, Childhood
Recruiting NCT05303467
A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM
Glioblastoma Multiforme · Recurrent Glioblastoma
Not yet recruiting NCT07739017
OLIG2 Inhibitor CT-179 for Recurrent and Newly-diagnosed Glioblastoma
Recurrent Glioblastoma · Newly Diagnosed MGMT Unmethylated Glioblastoma
Recruiting NCT07533942
A Study of JZP3507 (ONC206) in Recurrent Grade 2 or 3 Meningioma
Meningioma
Recruiting NCT04991870
Phase I CB-NK-TGF-ßR2-/NR3C1- in rGBM
Recurrent Gliosarcoma · Recurrent Supratentorial Glioblastoma · Supratentorial Gliosarcoma
Recruiting NCT07441707
A Study to Assess a Medicine Called Tovorafenib in Japanese Children and Young Adults With Brain Tumours
Low-grade Glioma
Recruiting NCT06991101
Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma
Glioblastoma · Brain Cancer · Glioblastoma Multiforme
Not yet recruiting NCT07735819
Positron Emission Tomography/Computed Tomography (PET/CT) Imaging in Patients Diagnosed With a Glioma
Low Grade Glioma · Glioblastoma
Recruiting NCT07076498
Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation
Glioma
Recruiting NCT03970447
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma
Glioblastoma
Recruiting NCT07464925
A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma
Glioblastoma Multiforme of Brain · Glioma · Glioblastoma
Recruiting NCT07416188
Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma
Recurrent Glioblastoma · Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype · Relapsed Cancer
Recruiting NCT05284643
Spectroscopic MRI, Proton Therapy, and Avastin for Recurrent Glioblastoma
Recurrent Glioblastoma
Recruiting NCT06161519
PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications
Glioma · Medulloblastoma · Ependymoma
Not yet recruiting NCT07649070
Phase 2 Trial of G207 + 5 Gy Radiation for Children With High-Grade Gliomas
High Grade Gliomas
Recruiting NCT07271966
B6 Administration for Levetiracetam-Associated Neurobehavioral Changes and Epilepsy
Brain Tumor Related Epilepsy (BTRE)
Recruiting NCT03911388
HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors
Neoplasms, Brain · Glioblastoma Multiforme · Glioblastoma of Cerebellum
Not yet recruiting NCT07732140
Listen Aphasia Pilot Study
Aphasia · Malignant Brain Tumor
Recruiting NCT07731555
Characterization of the Blood-Brain Barrier in High-Grade Glioma Through Immunohistochemical, Transcriptional, Fluorescein and Radiological Analyses
Glioblastoma
Recruiting NCT07428616
A Study of Zanzalintinib in Participants With Recurrent or Progressive Meningioma
Meningioma
Not yet recruiting NCT07725640
Feasibility Assessment of a Medical Device for Tumour Cell Retention and Radiotherapy Sensitization in Patients With Suspected High-grade Glioma
Glioma · High-Grade Glioma (HGG) · Surgical Resection
Recruiting NCT03922555
ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas
Neurological Cancer
Recruiting NCT05765812
A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma
Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype · Astrocytoma, Grade III
Not yet recruiting NCT07664176
NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors
Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma · High Grade Gliomas · Medulloblastoma Recurrent
Not yet recruiting NCT07703605
AI-Assisted MRI Molecular Subtyping in Pediatric Brain Tumors
Pediatric Brain Tumors · Glioma · Medulloblastoma
Not yet recruiting NCT07708961
Temozolomide, With or Without WSD0922-FU, for the Treatment of EGFR-Mutant, IDH-Wildtype Glioblastoma
Glioblastoma, IDH-Wildtype
Not yet recruiting NCT07719127
Study of Disulfiram to Reduce Myeloid Immunosuppression and Steroid Dependence in Resectable High Grade Glioma
Brain (Nervous System) Cancers
Recruiting NCT05879250
WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma
Glioblastoma, IDH-Wildtype · MGMT-Unmethylated Glioblastoma
Recruiting NCT04427384
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
Brain Tumor, Recurrent · Brain Tumor · Brain Tumor, Primary
Recruiting NCT06556563
EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma
Glioblastoma
Recruiting NCT05188508
Pembrolizumab, Olaparib, and Temozolomide for People With Glioma
Glioma
Recruiting NCT06672575
A Phase I/II Study of IVONESCIMAB in Recurrent Glioblastoma
Glioblastoma
Recruiting NCT06981156
Evaluation of the Neurologic Assessment in Pediatric Neuro-Oncology (pNANO)
Pediatric Brain Tumor · Pediatric Spine Tumor
Recruiting NCT07717827
Connectome-guided Onco-functional Resection With Tractography-Extended Neuronavigation in Brain Tumor Surgery
Brain (Nervous System) Cancers · Glioma · Brain Metastasases
Not yet recruiting NCT07488780
Language Network Prehab Via fMRI Neurofeedback
Glioma · Glioma Surgery
Not yet recruiting NCT07715357
Evaluation of The Radioprotective Effect of 3D-Printed Intraoral Stents in Children With Brain Cancer.
Medulloblastoma Tumor
Recruiting NCT05416567
Embolization for Meningioma
Meningioma
Recruiting NCT06910306
Alpha Radiation Emitters Device (DaRT) for the Treatment of Recurrent Glioblastoma
Recurrent Glioblastoma · Recurrent Gliomas
Not yet recruiting NCT07715097
Survivin-Targeted Dendritic Cell (DC) Cell Injection for Newly Diagnosed Glioblastoma
Glioblastoma
Recruiting NCT07089641
ERAS-801 for the Treatment of Resectable and Progressive or Recurrent or Elderly Newly Diagnosed IDH Wildtype Grade IV Glioblastoma or Gliosarcoma With an EGFR Amplification or Mutation, ERAS801-SARG Trial
Glioblastoma · Glioblastoma, IDH-Wildtype · Gliosarcoma
Recruiting NCT04479696
Customized Neuro-Imaging Referenced Symptom Video for the Reduction of Patient and Caregiver Anxiety Around Radiation Treatment for Brain Tumors
Glioblastoma · WHO Grade II Glioma · WHO Grade III Glioma
Not yet recruiting NCT07714551
Zanzalintinib in Unresectable and Progressive MPGGs
Pheochromocytoma · Paraganglioma
Not yet recruiting NCT07713745
Platform Research for Innovative Medicines in NF2-SWN (PRIME-NF2)
Neurofibromatosis Type 2 · Vestibular Schwannoma · Non-vestibular Schwannoma
Recruiting NCT06177964
Lerapolturev (PVSRIPO) in GBM
Recurrent Supratentorial Glioblastoma
Recruiting NCT07713550
The Added Value of Tissue or Liquid Biopsy NGS Profiling in Advanced Solid Tumor Treatment Decisions.
Advanced Solid Tumor Cancer · Primary CNS Tumors
Recruiting NCT07710040
Preoperative Proton Irradiation for High-grade Brain Gliomas.
High Grade Gliomas
Recruiting NCT07710690
A Clinical Trial Evaluating the Tolerability, Safety, and Preliminary Efficacy of NRG-103 Injection in Patients With Recurrent or Progressive High-grade Glioma
HGG · High Grade Glioma (III or IV) · High Grade Glioma
Not yet recruiting NCT07712770
Pilot Radioembolisation Clinical Trial Assessing Safety and Efficacy in Recurrent Glioma
Recurrent Glioblastoma IDH Wildtype · Recurrent Glioblastoma
Not yet recruiting NCT07710131
Neurocognitive Assessment CNSL and LGG
PCNSL · Brain Tumor · Cognitive Dysfunction
Recruiting NCT06185686
Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients
Brain Tumor, Primary
Recruiting NCT07225621
Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma
Glioblastoma · GBM
Not yet recruiting NCT07538791
Italian Multicenter Experience With Radioreceptor-assisted Therapy (PRRT)
Pheochromocytomas · Paragangliomas
Not yet recruiting NCT07712757
Safety and Efficacy Study of Safusidenib in Participants With Grade 2 IDH1-Mutant Glioma
Grade 2 Glioma (Astrocytoma or Oligodendroglioma) With an IDH1 Mutation · Astrocytoma IDH Mutant Grade 2 · Oligodendroglioma
Recruiting NCT05023018
NEO100 and High-Grade Meningioma
Residual, Progressive or Recurrent Grade II or III Meningioma
Not yet recruiting NCT07707973
Nimotuzumab Combined With the Stupp Regimen for Postoperative Residual Glioblastoma
Glioma, Malignant
Not yet recruiting NCT07707947
Selumetinib for NF2-Related Schwannomatosis
Neurofibromatosis Type 2 · NF2 · NF2-related Schwannomatosis
Recruiting NCT05382338
A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss
Childhood Medulloblastoma
Recruiting NCT07278440
An Exercise Intervention for Improving Mental and Physical Health in Patients With Primary Brain Tumors and Their Caregivers, ET-NEURO Trial
Primary Brain Neoplasm
Recruiting NCT03830151
Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors
Primary Brain Neoplasm
Not yet recruiting NCT07708285
Luvometinib in Combination With Serplulimab for NF2-Related Tumors
NF2-related Schwannomatosis · NF2 · Neurofibromatosis Type 2
Recruiting NCT06850766
The Feasibility and Efficacy of Dose Timing (Morning vs Evening) of Temozolomide in the Treatment of Glioblastoma
IDH-Wildtype Glioblastoma · Glioblastoma (GBM)
Recruiting NCT07703761
AI-driven Processing and Analysis of Glioma Imaging Data
Glioma · Glioma (Diagnosis)
Not yet recruiting NCT07472790
A Study on the Novel Oncolytic Virus Combined With PD-1 Inhibitor in the Treatment of Recurrent High-grade Glioma
High-grade Glioma
Not yet recruiting NCT07703436
Safety and Efficacy Study of Safusidenib in Participants With IDH1-Mutant Glioma Who Discontinued Vorasidenib Treatment Due to Progressive Disease
Grade 2 IDH1-mutant Glioma · Grade 3 IDH1-mutant Glioma · Glioma
Recruiting NCT07398170
Search for Circulating Tumour Cells in the Blood and/or Cerebrospinal Fluid in Patients With Recurrent Aggressive Meningiomas: Proof-of-concept Study
Meningioma
Recruiting NCT06942039
Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation
CNS Embryonal Tumor · CNS, Medulloblastoma · Atypical Teratoid Rhabdoid Tumor
Recruiting NCT05660369
CARv3-TEAM-E T Cells in Glioblastoma
Glioblastoma · Malignant Glioma · Recurrent Glioblastoma
Recruiting NCT05077735
Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Trial
Diffuse Midline Glioma, H3 K27M-Mutant
Recruiting NCT03948490
Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas
Low-grade Glioma
Recruiting NCT05989893
Mapping of Human Cognition
Epilepsy · Brain Tumor
Recruiting NCT06344130
Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma
Astrocytoma · Glioma · Recurrent Glioblastoma
Not yet recruiting NCT07698457
Clinical Benefit of 18F-FET in Glioma.
Glioma · 18F-Fluoroethyl-l-tyrosine