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Not yet recruiting NCT07612839

Intravenous Lidocaine for Postoperative Fatigue After Laparoscopic TAPP Inguinal Hernia Repair

No phase Interventional Postoperative Fatigue Syndrome Inguinal Hernia Unilateral

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Lidocaine.
Who it may be relevant to
Registry conditions: Postoperative Fatigue Syndrome, Inguinal Hernia Unilateral. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

The Effect of Intravenous Lidocaine on Postoperative Fatigue Syndrome in Patients Undergoing Elective Laparoscopic TAPP Inguinal Hernia Repair

Overview

This prospective randomized controlled study aims to evaluate the effect of perioperative intravenous lidocaine infusion on postoperative fatigue syndrome in patients undergoing elective laparoscopic TAPP inguinal hernia repair. Participants will be randomly assigned to receive either intravenous lidocaine infusion or standard perioperative management without lidocaine. The primary objective is to assess postoperative fatigue and recovery quality. Secondary outcomes include postoperative pain, analgesic consumption, nausea-vomiting, mobilization time, and length of hospital stay.

Detailed description

Postoperative fatigue syndrome is a common problem after surgery and may negatively affect recovery quality, mobilization, and patient satisfaction. Intravenous lidocaine has anti-inflammatory, antihyperalgesic, and opioid-sparing properties that may improve postoperative recovery outcomes.

This prospective randomized controlled trial will include adult patients undergoing elective laparoscopic transabdominal preperitoneal (TAPP) inguinal hernia repair under general anesthesia. Eligible participants will be randomly allocated into two groups. The lidocaine group will receive perioperative intravenous lidocaine infusion according to the study protocol, while the control group will receive standard perioperative care without lidocaine infusion.

The primary outcome of the study is postoperative fatigue syndrome. Secondary outcomes include postoperative pain scores, opioid consumption, postoperative nausea and vomiting, time to mobilization, and duration of hospital stay.

The study is designed as an investigator-initiated academic clinical trial conducted at a tertiary training and research hospital in Türkiye.

Interventions

  • Drug Lidocaine
    Perioperative intravenous lidocaine infusion will be administered according to the study protocol in patients undergoing elective laparoscopic TAPP inguinal hernia repair.

Primary outcome measures

  • Postoperative Fatigue Syndrome Score [Time frame: Postoperative days 1, 3, 5]
Secondary outcome measures (3)
  • Postoperative Pain Score [Time frame: Postoperative days 1, 3, and 5]
  • Opioid Consumption [Time frame: Within postoperative 24 hours]
  • Postoperative Nausea and Vomiting [Time frame: Within postoperative 24 hours]

Eligibility criteria

Inclusion criteria

Adult patients aged 18 years and older Patients scheduled for elective laparoscopic TAPP inguinal hernia repair under general anesthesia ASA physical status I-II Patients who provide written informed consent -

Exclusion criteria

Moderate to severe hepatic dysfunction Low cardiac output or severe heart failure Severe cardiac conduction abnormalities or clinically significant arrhythmias Planned concomitant use of high-dose local anesthetics, including infiltration or regional block Advanced age or frailty Pregnancy or breastfeeding Known allergy or contraindication to lidocaine Refusal to participate in the study

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Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

Turkey (Türkiye) · 1 center
  • University of Health Sciences Sultan Abdulhamid Han Training and Research Hospital — Istanbul

Identifiers

NCT: NCT07612839 · 25-42

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗