Diagnostic Performance and Quantitative Analysis of [18F]FET PET in Brain Tumours
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Brain Tumors. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This is a retrospective study encompassing all \[18F\]FET PET scans performed at our centre. By analysing both static and dynamic scans, conducting in-depth kinetic modelling, and comparing quantitative parameters across different tumour types and clinical contexts, the study aims to determine the true diagnostic value of \[18F\]FET PET in everyday clinical practice. The ultimate goal is to identify imaging biomarkers useful for improving tumour characterisation and distinguishing recurrence from post-treatment changes, thereby strengthening the role of \[18F\]FET PET in modern neuro-oncology.
Primary outcome measures
- Primary outcome [Time frame: Retrospective analysis of data acquired up to December 31, 2025.]
Secondary outcome measures (5)
- Secondary Outcome Measure [Time frame: Up to December 31, 2025.]
- Diagnostic Outcome Measure [Time frame: Up to December 31, 2025.]
- Quantitative outcome [Time frame: Up to December 31, 2025.]
- Secondary Outcome Measure [Time frame: Up to December 31, 2025]
- Secondary Outcome Measure [Time frame: Up to December 31, 2025.]
Eligibility criteria
Inclusion criteria
- Patients who underwent a brain PET/CT or PET/MRI scan with \[18F\]FET for clinical reasons during the study period.
- Age ≥ 18 years.
- Indication for the scan related to diagnosis, grading, assessment of treatment response or suspected recurrence of any brain tumour (primary or metastatic).
- Availability of the corresponding static and dynamic images.
- Signed informed consent.
Exclusion criteria
- . Pregnancy or breastfeeding
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07599917 · FET-BRAIN-DX