Brain Cognitive Network Abnormalities in Anemia Patients Using fNIRS
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Aplastic Anemia, Myelodysplastic Syndromes, Autoimmune Hemolytic Anemia, Functional Near-Infrared Spectroscopy. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Construction of Abnormal Projection Regions of Cognitive Neural Networks in Patients With Anemia Using Functional Near-Infrared Spectroscopy (fNIRS)
Overview
Anemia is a global public health concern and is closely linked to dysfunction of brain cognitive neural networks, a key mechanism underlying cognitive impairment. Such deficits-including declines in memory, learning, processing speed, and executive function-reduce daily living abilities and increase risks of falls and depression. Functional near-infrared spectroscopy (fNIRS) enables real-time monitoring of oxygenated and deoxygenated hemoglobin fluctuations, reflecting brain network function. This study aims to identify affected neural network regions in anemic patients and visualize connectivity changes using heatmaps and arc-based mapping. The findings will support early detection of cognitive impairment and guide precise clinical interventions, ultimately informing individualized treatment strategies to enhance therapeutic outcomes and quality of life.
Primary outcome measures
- Concentration changes in oxygenated hemoglobin (HbO) and de-oxygenated hemoglobin (HbR) [Time frame: Patients will be assessed within 48 hours of admission.]
- Cognitive Function Assessment [Time frame: Patients will be assessed within 48 hours of admission.]
Secondary outcome measures (5)
- Anxiety symptoms [Time frame: Patients will be assessed within 48 hours of admission.]
- Depression symptoms [Time frame: Patients will be assessed within 48 hours of admission.]
- Sleep quality [Time frame: Patients will be assessed within 48 hours of admission.]
- Physical fatigue [Time frame: Patients will be assessed within 48 hours of admission.]
- Appetite condition [Time frame: Patients will be assessed within 48 hours of admission.]
Eligibility criteria
Inclusion criteria
- Diagnosis of anemia
- First hospitalization
- Male or female, aged 18-65 years
- Willing and able to comply with the requirements for this study and written informed consent
Exclusion criteria
- History of psychiatric illness
- History of severe brain disease
- Subjects that the investigator believes have other reasons that make them unsuitable for inclusion in this study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Regenerative Medicine Center — Tianjin
Identifiers
NCT: NCT07578675 · QTJC2026037