Triggering Ovulation in Normo-responders Using a Modified Dual Trigger Protocol or HCG Trigger
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Modified dual trigger, HCG.
- Who it may be relevant to
- Registry conditions: Infertility (IVF Patients). Basic parameters: 18 years — 40 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Triggering Ovulation in Normo-responders Using a Modified Dual Trigger Protocol or HCG Trigger . A Randomized Controlled Study
Overview
The aim of this randomized controlled study is to compare the efficacy of a modified dual trigger protocol \[a single bolos of HCG combined with two successive doses of a GnRH agonist \] with HCG \[a single bolos administered 36 hours before oocyte retrieval \] in triggering ovulation in normo-responders undergoing ovarian stimulation using the antagonist protocol.
Interventions
- Drug Modified dual trigger
HCG (10000 IU /IM) and triptorelin (0.2 mg/S.C) are administered 36 hours before ovum pickup . Moreover, 0.1mg of triptorelin is administered 24 h prior to ovum pick-up. - Drug HCG
HCG (10000 IU/IM ) is administered 36 hours before ovum pickup.
Primary outcome measures
- Metaphase-II oocytes rate [Time frame: Ten to fifteen days after starting ovarian stimulation]
Secondary outcome measures (2)
- Clinical pregnancy rate [Time frame: Five weeks after embryo transfer]
- Ongoing pregnancy Rate [Time frame: Eighteen weeks after embryo transfer]
Eligibility criteria
Inclusion criteria
- GnRH antagonist IVF cycle
- Normo-responders to induction of ovulation
Exclusion criteria
- Hypogonadotrophic hypogonadism
- Endometriosis
- History of recurrent abortion
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Bedaya Hospital — Giza
Identifiers
NCT: NCT07569302 · Dual trigger/normo-responders