Diet and WB-EMS Effects in Obesity
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Energy-Restricted Diet, Whole-Body Electromyostimulation (WB-EMS).
- Who it may be relevant to
- Registry conditions: Obesity & Overweight, Metabolic Disorders, Electrotherapy. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Effects of Energy-Restricted Diet and Whole-Body Electromyostimulation (WB-EMS) on Myokine-Adipokine Interaction, Appetite Regulation, and Body Composition in Obese Individuals: A Randomized Controlled Trial
Overview
Obesity is a major global health problem associated with metabolic dysfunction, altered adipokine signaling, and impaired appetite regulation. Conventional weight loss strategies such as calorie restriction often result in compensatory physiological adaptations, including increased appetite and loss of lean body mass, which may limit long-term effectiveness. Whole-body electromyostimulation (WB-EMS) is an emerging, time-efficient intervention that induces simultaneous muscle activation and may improve metabolic health. However, the underlying molecular mechanisms, particularly the interaction between myokines and adipokines, remain insufficiently understood. This randomized controlled trial aims to investigate the effects of an energy-restricted diet combined with WB-EMS on myokine-adipokine interaction, appetite regulation, and body composition in obese individuals. Participants will be randomly assigned to either a diet-only group or a diet plus WB-EMS group for 8 weeks. Primary outcomes include changes in serum irisin levels. Secondary outcomes include myostatin, leptin, adiponectin, FGF-21, ghrelin, GLP-1, body composition parameters, and eating behavior. The findings of this study are expected to provide novel insights into the physiological and molecular effects of WB-EMS as a complementary strategy in obesity management.
Interventions
- Behavioral Energy-Restricted Diet
A personalized diet with approximately 750 kcal/day energy deficit. - Device Whole-Body Electromyostimulation (WB-EMS)
Whole-body electromyostimulation applied 2-3 times per week for 8 weeks under supervision.
Primary outcome measures
- Change in serum irisin levels [Time frame: Baseline to 8 weeks]
Secondary outcome measures (10)
- Change in serum myostatin levels [Time frame: Baseline to 8 weeks]
- Change in serum leptin levels [Time frame: Baseline to 8 weeks]
- Change in serum adiponectin levels [Time frame: Baseline to 8 weeks]
- Change in serum FGF-21 levels [Time frame: Baseline to 8 weeks]
- Change in serum ghrelin levels [Time frame: Baseline to 8 weeks]
- Change in serum GLP-1 levels [Time frame: Baseline to 8 weeks]
- Change in fat mass [Time frame: Baseline to 8 weeks]
- Change in fat-free mass [Time frame: Baseline to 8 weeks]
- Change in body fat percentage [Time frame: Baseline to 8 weeks]
- Change in eating behavior scores [Time frame: Baseline to 8 weeks]
Eligibility criteria
Inclusion criteria
- Age between 18 and 65 years
- Body mass index (BMI) ≥ 30 kg/m²
- Sedentary lifestyle (less than 2 hours of structured exercise per week)
- Willingness to participate and provide written informed consent
Exclusion criteria
- Presence of pacemaker or implantable cardioverter-defibrillator
- Known cardiovascular disease or severe chronic illness
- Pregnancy or breastfeeding
- Uncontrolled diabetes or severe metabolic disorders
- Active malignancy or cancer treatment
- Severe renal or hepatic failure
- Acute infection or inflammatory disease
- Orthopedic conditions limiting physical activity
- Use of medications affecting body composition or appetite (e.g., corticosteroids, weight-loss drugs)
- Regular resistance training within the last 3 months
- Substance abuse, including alcohol or drug dependency
- Psychiatric or cognitive conditions affecting adherence to the study protocol
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Turkey (Türkiye) · 2 centers
- Dicle University — Diyarbakır
- Firat University — Elâzığ
Identifiers
NCT: NCT07562724 · FU_MGBeydagi_EMS_B_2026/05