The Impact of Surgical Procedures on Postoperative Outcomes in Cataract Phacoemulsification and Analysis of Related Factors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: cataract surgery.
- Who it may be relevant to
- Registry conditions: Age-related Cataract. Basic parameters: 50 years — 90 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The goal of this observational study is to evaluate the location of phacoemulsification tip measured by intraoperative OCT during cataract surgeries and its impact on early postoperative changes of cornea and visual acuity. The main question it aims to answer is: In patients with age-related cataracts undergoing phacoemulsification, does the location (supracapsular, iris-lens diaphragm, or endocapsular) of the phaco tip affect postoperative corneal changes and visual acuity at early postoperative stage? Eyes having phacoemulsification for cataracts will receive intraoperative OCT imaging to evaluate the location of the phaco tip during surgery, and corneal changes and visual acuity will be measured postoperatively.
Interventions
- Procedure cataract surgery
Cataract phacoemulsification combined with intraocular lens implantation
Primary outcome measures
- Change in corneal thickness [Time frame: postoperative day 1, week 1, and month 1]
Secondary outcome measures (3)
- Change in corneal endothelial cell density [Time frame: 1 day, 1 week, and 1 month postoperatively]
- Best-corrected visual acuity [Time frame: 1 day, 1 week, and 1 month postoperatively]
- Intraoperative and postoperative complications [Time frame: Intraoperative, 1 day, 1 week, and 1 month postoperatively]
Eligibility criteria
Inclusion criteria
- Age ≥ 50 years and ≤ 90 years
- Diagnosis of unilateral/bilateral age-related cataract
- Nuclear grade ≥2 in LOCSIII classification
- Scheduled for cataract phacoemulsification combined with intraocular lens implantation
- Pupil size ≥6mm after dilation
- Corneal endothelial cell count ≥1500 cells/mm²
Exclusion criteria
- Diagnosis of severe systemic disease (e.g., severe hypertension or Alzheimer's disease)
- History of ocular trauma or surgery
- Presence of other ocular diseases (such as glaucoma, diabetic retinopathy, or high myopia)
- Other ocular factors that may complicate the surgery (such as small pupil, shallow anterior chamber)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Zhongshan Ophthalmic Center, Sun Yat-sen University — Guangzhou
Publications
- Liu Z, Lin H, Jin L, Qu B, Liu J, Zheng Y, He M, Luo L, Liu Y. Swab Pressing vs Stromal Hydration to Prevent Incision Leakage and Transient Collapse of Anterior Chamber in Phacoemulsification: A Randomized Clinical Trial. JAMA Ophthalmol. 2023 Jun 1;141(6):574-581. doi: 10.1001/jamaophthalmol.2023.1491. PMID 37166786
- Liu Y, Zeng M, Liu X, Luo L, Yuan Z, Xia Y, Zeng Y. Torsional mode versus conventional ultrasound mode phacoemulsification: randomized comparative clinical study. J Cataract Refract Surg. 2007 Feb;33(2):287-92. doi: 10.1016/j.jcrs.2006.10.044. PMID 17276271
- Dewan T, Malik PK, Kumari R. Comparison of effective phacoemulsification time and corneal endothelial cell loss using 2 ultrasound frequencies. J Cataract Refract Surg. 2019 Sep;45(9):1285-1293. doi: 10.1016/j.jcrs.2019.04.015. Epub 2019 Jul 29. PMID 31371150
- Dewan T, Malik PK, Tomar P. Comparison of effective phacoemulsification time and corneal endothelial cell loss using three different ultrasound frequencies: A randomized controlled trial. Indian J Ophthalmol. 2022 Apr;70(4):1180-1185. doi: 10.4103/ijo.IJO_2163_21. PMID 35326010
- Liu Y, Jiang Y, Wu M, Liu Y, Zhang T. Bimanual microincision phacoemulsification in treating hard cataracts using different power modes. Clin Exp Ophthalmol. 2008 Jul;36(5):426-30. PMID 18939349
- Lundberg B, Jonsson M, Behndig A. Postoperative corneal swelling correlates strongly to corneal endothelial cell loss after phacoemulsification cataract surgery. Am J Ophthalmol. 2005 Jun;139(6):1035-41. doi: 10.1016/j.ajo.2004.12.080. PMID 15953433
Identifiers
NCT: NCT07550907 · IIT2025172