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Not yet recruiting NCT07508137

Digital PrEP Micro-Intervention for PWUD in Kazakhstan

No phase Interventional Drug Use HIV

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Dgital micro-intervention.
Who it may be relevant to
Registry conditions: Drug Use, HIV. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Kazakhstan
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Digital Micro-Interventions to Reduce Stigma-Driven Barriers and Improve PrEP Readiness Among People Who Use Drugs in Kazakhstan

Overview

This study is a mixed-methods pilot designed to evaluate the feasibility, acceptability, and appropriateness of a brief digital micro-intervention aimed at reducing stigma-related barriers to pre-exposure prophylaxis (PrEP) engagement among people who use drugs (PWUD) in Kazakhstan. Participants will complete baseline and post-intervention surveys and receive structured informational content via Telegram or WhatsApp over approximately 2-3 weeks. The intervention focuses on addressing anticipated stigma, confidentiality concerns, and misinformation that may prevent PWUD from seeking PrEP services. No clinical procedures, medication provision, or biological specimen collection are involved.

Detailed description

The proposed study has three aims:

1. To refine a brief, stigma-informed digital micro-intervention designed to address structural and anticipated barriers to PrEP uptake among people who use drugs (PWUD) in Kazakhstan. 2. To assess the feasibility, acceptability, and appropriateness of delivering this intervention through secure digital platforms (e.g., Telegram or WhatsApp). 3. To evaluate preliminary changes in PrEP-related knowledge, perceived stigma- related barriers, and readiness to seek PrEP services following exposure to the intervention.

Interventions

  • Behavioral Dgital micro-intervention
    Intervention will include 6-10 brief modules delivered asynchronously consisting of text-based content with optional simple visuals. There is no requirement for participant response. Messages will avoid explicit labeling referencing HIV or drug use in preview text and be written using neutral language. Participants are allowed to discontinue receipt at any time.

Primary outcome measures

  • Mean Score Acceptability of Intervention Measure (AIM) [Time frame: Baseline and Post intervention (Week 4)]
  • Mean Score Intervention Appropriateness Measure (IAM) [Time frame: Baseline and Post intervention (Week 4)]
  • Mean Score Feasibility of Intervention Measure (FIM) [Time frame: Baseline and Post intervention (Week 4)]
Secondary outcome measures (5)
  • Change in PrEP knowledge [Time frame: Baseline and Post intervention (Week 4)]
  • Change in perceived stigma-related barriers [Time frame: Baseline and Post intervention (Week 4)]
  • Change in readiness to seek PrEP [Time frame: Baseline and Post intervention (Week 4)]
  • Mean number of clicks or links accessed [Time frame: Baseline and Post intervention (Week 4)]
  • Mean number of messages delivered [Time frame: Baseline and Post intervention (Week 4)]

Eligibility criteria

Inclusion criteria

  • Self-reported drug use within the past six months
  • HIV-negative or unknown HIV status (self-reported)
  • Not currently taking PrEP
  • Able to provide informed consent
  • Have access to a personal mobile phone capable of receiving Telegram or WhatsApp messages

Exclusion criteria

  • Are unable to provide informed consent
  • Do not have access to a mobile device for digital message delivery
  • Are currently enrolled in another PrEP behavioral intervention study

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Supportive care

Study locations

Kazakhstan · 1 center
  • Center for Scientific and Practical Initiatives — Almaty

Identifiers

NCT: NCT07508137 · 2000042287 · 2P30MH062294-21

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗