Digital PrEP Micro-Intervention for PWUD in Kazakhstan

Официальное название

Digital Micro-Interventions to Reduce Stigma-Driven Barriers and Improve PrEP Readiness Among People Who Use Drugs in Kazakhstan

Обзор

This study is a mixed-methods pilot designed to evaluate the feasibility, acceptability, and appropriateness of a brief digital micro-intervention aimed at reducing stigma-related barriers to pre-exposure prophylaxis (PrEP) engagement among people who use drugs (PWUD) in Kazakhstan. Participants will complete baseline and post-intervention surveys and receive structured informational content via Telegram or WhatsApp over approximately 2-3 weeks. The intervention focuses on addressing anticipated stigma, confidentiality concerns, and misinformation that may prevent PWUD from seeking PrEP services. No clinical procedures, medication provision, or biological specimen collection are involved.

Подробное описание

The proposed study has three aims:

1. To refine a brief, stigma-informed digital micro-intervention designed to address structural and anticipated barriers to PrEP uptake among people who use drugs (PWUD) in Kazakhstan. 2. To assess the feasibility, acceptability, and appropriateness of delivering this intervention through secure digital platforms (e.g., Telegram or WhatsApp). 3. To evaluate preliminary changes in PrEP-related knowledge, perceived stigma- related barriers, and readiness to seek PrEP services following exposure to the intervention.

Вмешательства

• Поведенческое Dgital micro-intervention
  Intervention will include 6-10 brief modules delivered asynchronously consisting of text-based content with optional simple visuals. There is no requirement for participant response. Messages will avoid explicit labeling referencing HIV or drug use in preview text and be written using neutral language. Participants are allowed to discontinue receipt at any time.

Первичные конечные точки

• Mean Score Acceptability of Intervention Measure (AIM) [Срок оценки: Baseline and Post intervention (Week 4)]
• Mean Score Intervention Appropriateness Measure (IAM) [Срок оценки: Baseline and Post intervention (Week 4)]
• Mean Score Feasibility of Intervention Measure (FIM) [Срок оценки: Baseline and Post intervention (Week 4)]

Вторичные конечные точки (5)

• Change in PrEP knowledge [Срок оценки: Baseline and Post intervention (Week 4)]
• Change in perceived stigma-related barriers [Срок оценки: Baseline and Post intervention (Week 4)]
• Change in readiness to seek PrEP [Срок оценки: Baseline and Post intervention (Week 4)]
• Mean number of clicks or links accessed [Срок оценки: Baseline and Post intervention (Week 4)]
• Mean number of messages delivered [Срок оценки: Baseline and Post intervention (Week 4)]

Критерии участия

Критерии включения

• Self-reported drug use within the past six months
• HIV-negative or unknown HIV status (self-reported)
• Not currently taking PrEP
• Able to provide informed consent
• Have access to a personal mobile phone capable of receiving Telegram or WhatsApp messages

Критерии исключения

• Are unable to provide informed consent
• Do not have access to a mobile device for digital message delivery
• Are currently enrolled in another PrEP behavioral intervention study

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Поддерживающая терапия

Центры проведения

Казахстан · 1 центр

• Center for Scientific and Practical Initiatives — Almaty

Идентификаторы

NCT: NCT07508137 · 2000042287 · 2P30MH062294-21

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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