Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Ischemic preconditioning, NO ischemic preconditioning.
- Who it may be relevant to
- Registry conditions: Renal Cell Carcinoma (RCC), Renal Function Abnormal. Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy: a Randomized Controlled Clinical Study
Overview
It is demonstrated that remote ischemic preconditioning can alleviate the degree of acute renal injury on the operated side in patients undergoing partial nephrectomy.
Detailed description
The study cohort was randomly divided into two groups. One group received remote ischemic preconditioning one day before partial nephrectomy, while the other group underwent partial nephrectomy directly. The degree of acute renal injury on the operated side was compared between the two groups
Interventions
- Procedure Ischemic preconditioning
One day before the surgery, use a sphygmomanometer to apply pressure to the patient's upper limb to 200mmHg for 5 minutes, then reduce the pressure to 0mmHg for 5 minutes, repeating this process for a total of 3 cycles. On the second day, perform a routine partial nephrectomy - Procedure NO ischemic preconditioning
Routine partial nephrectomy
Primary outcome measures
- AIRD spectrum score based on the patient's preoperative creatinine level and postoperative peak creatinine level [Time frame: 2 weeks after partial nephrectomy]
Secondary outcome measures (1)
- Recovery from ischemia based on the changes in creatinine levels before and after the partial nephrectomy and volume retention rate after the partial nephrectomy [Time frame: 3 month after surgery]
Eligibility criteria
Inclusion criteria
- Patients who are scheduled to undergo partial nephrectomy, with no specific surgical procedure limitation, including laparoscopic surgery, robot-assisted surgery, and open surgery
- Aged 18 to 80
- Possess good organ function status: sufficient organ function (based on the normal values of the clinical trial center)
- Blood routine test: WBC≥3.5×10\^9/L, absolute neutrophil count ≥1.5×10\^9/L, PLT≥75.0×10\^9/L, HGB≥80g/L;
- Liver function: Total bilirubin ≤1.5×upper limit of normal (ULN), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5×ULN;
Exclusion criteria
- The anesthesiologist assesses that the patient cannot tolerate general anesthesia surgery
- Individuals with severe cardiovascular and cerebrovascular diseases, uncontrolled hypertension, and diabetes
- Estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73m²
- Horseshoe kidney
- Solitary kidney
- Pregnant women
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
China · 1 center
- 651 Dongfeng Road East, Yuexiu District, Guangzhou, P.R. China Sun Yat-sen University Canc — Guangzhou
Identifiers
NCT: NCT07497958 · B2026-114