Diagnostic Value and Safety of Combined Biopsy for Mediastinal Metastasis of Lung Cancer
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: EBUS-TBMCB.
- Who it may be relevant to
- Registry conditions: Mediastinal Metastases of Lung Cancer. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Diagnostic Value and Safety of EBUS-TBNA Combined With Medaistinal Cryobiopsy for Mediastinal Metastasis of Lung Cancer
Overview
The study is aimed o evaluate the diagnostic performance and treatment guidance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) combined with transbronchial mediastinal cryobiopsy (EBUS-TBMCB) in patients with mediastinal metastases of lung cancer.
Detailed description
A traditional method, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), will serve as control. Enrolled patients will be randomly assigned to two groups: the experimental group, which will undergo EBUS-guided transbronchial mediastinal cryobiopsy (EBUS-TBMCB) following EBUS-TBNA, and control group, which will undergo EBUS-TBNA alone. Biopsy specimens from both groups will be analyzed by pathologists. All patients will be followed up to confirm the diagnosis and to document any complications. The diagnostic yield for lung cancer and the incidence of procedure-related adverse events will be compared between the two groups.
Interventions
- Procedure EBUS-TBMCB
Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy will be performed in experimental arm following EBUS-TBNA
Primary outcome measures
- Diagnostic yield for lung cancer [Time frame: From the date of biopsy sample acquisition to the date of follow-up completion, approximately 12 months]
Secondary outcome measures (5)
- Diagnostic accuracy [Time frame: From the date of biopsy sample acquisition to the date of follow-up completion, approximately 12 months]
- Sample size [Time frame: From the date of biopsy sample acquisition to the date of follow-up completion, approximately 12 months]
- Suitability for molecular assays [Time frame: From the date of biopsy sample acquisition to the date of follow-up completion, approximately 12 months]
- Duration of bronchoscopic procedure [Time frame: From the date of biopsy sample acquisition to the date of follow-up completion, approximately 12 months]
- Incidence of procedure-related adverse events [Time frame: Within 30 days post-biopsy]
Eligibility criteria
Inclusion criteria
- Aged ≥18 years;
- Presence of at least one mediastinal lesion (short-axis diameter ≥10 mm) confirmed by thin-slice chest CT;
- Patients who have not undergone prior mediastinal biopsy and require further mediastinal biopsy to confirm etiology or pathological subtype, meeting at least one of the following criterias:
(1) suspected lung cancer diagnosed by two senior physicians; (2) confirmed lung cancer (requiring mediastinal staging); (3) recurrent lung cancer; 4.Patients must have completed all required preoperative laboratory tests and necessary examinations (e.g., cardiac ultrasound, CTA) to rule out contraindications; 5. Patients are informed and capable of providing written informed consent.
Exclusion criteria
- Presence of severe cardiopulmonary disease, coagulation disorders, massive hemoptysis, poor tolerance to anesthesia, or other contraindications related to bronchoscopy;
- Intraoperative endobronchial ultrasound exploration of the lesion failed to detect the target lesion despite > 20 minutes of attempts;
- Lesions identified as abscesses or cysts;
- Presence of mental illness, severe neurosis, or other conditions that preclude the provision of informed consent;
- Patients who have participated in other clinical trials within 3 months;
- Any other conditions considered to be inappropriate to be involved in this trial.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Diagnostic
Study locations
China · 1 center
- Third Military Medical University — Chongqing
Identifiers
NCT: NCT07488507 · 2026-Research No. 038-02