Magnetic Resonance Imaging of the Lung: Oncological Applications
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Lung Cancer (NSCLC). Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Lung neoplasms are characterized by a complex interaction between tumor cells and a variety of resident and infiltrating host elements, secreted factors, and extracellular matrix proteins, collectively referred to as the microenvironment. Nowadays, in the setting of lung cancer, and in particular non-small cell lung cancer (NSCLC), the evaluation of microenvironment characteristics can only be performed by a pathologist and only on histological material. By combining different MRI parameters, it may be possible to create a specific imaging "signature" for the three different immune phenotypes and thus be able to make a distinction based on MRI examination.
Primary outcome measures
- assessment of the ability of advanced magnetic resonance imaging techniques to distinguish between immune phenotypes in NSCLC. [Time frame: up to 36 months]
Eligibility criteria
Inclusion criteria
- Primary NSCLC of the lung (TNM 8th edition T parameter ≥T1c)
- Biopsy examination of the primary tumor adequate at least for PDL-1 quantification
- Staging CT scan with uncertain N parameter and definite M parameter.
Exclusion criteria
- Absolute contraindications to magnetic resonance imaging or the administration of gadolinium-based contrast agents
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
Italy · 1 center
- Fondazione IRCCS Policlinico San Matteo — Pavia
Identifiers
NCT: NCT07486219 · P_113103