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Not yet recruiting NCT07477574

Muscle-Specific Multimodal AI for Sarcopenia Diagnosis

No phase Interventional Sarcopenia

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Rehabilitation training.
Who it may be relevant to
Registry conditions: Sarcopenia. Basic parameters: 65 years — 85 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Development of Muscle-specific Multi-modal AI for Sarcopenia Diagnosis: Effects of Rehabilitation Training on Ant-muscle Aging

Overview

This study aims to develop a muscle-specific multimodal artificial intelligence (AI) model for the diagnosis of sarcopenia and to investigate the effects of rehabilitation training on muscle aging. Clinical, functional, and imaging data will be collected from participants with muscle function decline. Multimodal data, including muscle function measurements and clinical assessments, will be integrated to develop and validate an AI-based diagnostic model for sarcopenia. In addition, the effects of rehabilitation training on muscle function and muscle aging-related outcomes will be evaluated. The results of this study are expected to contribute to the development of digital biomarkers and precision rehabilitation strategies for sarcopenia.

Interventions

  • Behavioral Rehabilitation training
    Participants will perform a structured rehabilitation training program designed to improve muscle strength, physical performance, and muscle function. Clinical assessments and muscle function measurements will be collected before and after the rehabilitation program to evaluate the effects of training and to support the development of a muscle-specific multimodal AI model for sarcopenia diagnosis.

Primary outcome measures

  • AI model performance [Time frame: Baseline to 12 weeks after rehabilitation training]
Secondary outcome measures (8)
  • Five-Times Chair Stand Test (5×STS) [Time frame: Baseline to 12 weeks after rehabilitation training]
  • Gait Speed [Time frame: Baseline to 12 weeks after rehabilitation training]
  • Appendicular Skeletal Muscle Mass (DEXA) [Time frame: Baseline to 12 weeks after rehabilitation training]
  • Appendicular Skeletal Muscle Mass (BIA) [Time frame: Baseline to 12 weeks after rehabilitation training]
  • Sarcopenia Screening [Time frame: Baseline to 12 weeks after rehabilitation training]
  • Handgrip Strength [Time frame: Baseline to 12 weeks after rehabilitation training]
  • Single Muscle Fiber Contractile Properties [Time frame: Baseline to 12 weeks after rehabilitation training]
  • Short Physical Performance Battery (SPPB) [Time frame: Time Frame: Baseline to 12 weeks after rehabilitation training]

Eligibility criteria

Inclusion criteria

  • Adults aged 65 years or older
  • Individuals with reduced muscle function or at risk of sarcopenia
  • Able to participate in rehabilitation training
  • Able to understand the study procedures and provide written informed consent

Exclusion criteria

  • Severe cardiovascular, neurological, or musculoskeletal conditions that limit participation in exercise
  • Severe cognitive impairment
  • Participation in other clinical trials that may influence study outcomes
  • Any medical condition judged by the investigator to make participation unsafe

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Basic science

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT07477574 · B-2505-970-002 · RS-2025-00560295

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗