Culturally Adapting an Intervention to Increase Genetic Testing in African American Cancer Survivors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Culturally adapted Online Genetic Counseling and Testing Information.
- Who it may be relevant to
- Registry conditions: Female Breast Cancer, Prostate Cancer, Colorectal Carcinoma. Basic parameters: 20 years — 79 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
A Community-Engaged Approach to Culturally Adapting an Intervention to Increase Uptake of Genetic Testing Among African American Cancer Survivors
Overview
The goal of this clinical trial is to culturally adapt an educational genetic counseling intervention to increase the uptake in genetic counseling and testing among African Americans at risk for heredity cancers. With the help of community stakeholders and clinical genetic professionals the investigators will: * adapt and refine a culturally relevant online educational genetic counseling program for at-risk African Americans * Test the effects of the educational program * collaborate with community leaders and clinical genetic professionals to translate study findings, develop a road map for dissemination to the community, and identify barriers to prepare for future trials. Participants from Detroit Research on Cancer Survivor group will be offered enrollment. Once consent is obtained, questionnaires will be completed before an online genetic counselling intervention immediately after, and at 3 months
Interventions
- Behavioral Culturally adapted Online Genetic Counseling and Testing Information
Testing the effects of the educational intervention designed to increase the uptake of genetic counseling testing among at-risk African American survivors
Primary outcome measures
- Uptake of genetic counseling and genetic testing [Time frame: 3 month follow Up]
Secondary outcome measures (12)
- Intention to undergo genetic counseling and testing [Time frame: 1 day Pre Intervention to 1 day Post Intervention]
- Sharing Your Results [Time frame: 3 month follow up]
- Major Experiences of Discrimination [Time frame: 1 day prior to intervention]
- Everyday Experiences of Discrimination [Time frame: 1 day prior to intervention]
- Interpersonal Processes of Care Survey [Time frame: 1 day prior to intervention]
- Group-Based Medical Mistrust Scale [Time frame: 1 day prior to intervention]
- Perceived Access to Health Care Services [Time frame: 1 day prior to intervention]
- Perceived risk of carrying genetic mutation [Time frame: 1 day Pre Intervention to 1 day Post Intervention]
- Attitudes about genetic counseling and testing [Time frame: 1 day Pre Intervention to 1 day Post Intervention]
- Behavioral beliefs about genetic counseling [Time frame: 1 day Pre Intervention to 1 day Post Intervention]
- Perceived norms [Time frame: 1 day Pre Intervention to 1 day Post Intervention]
- Knowledge of Genetic Counseling [Time frame: 1 day Pre Intervention to 1 day Post Intervention]
Eligibility criteria
Inclusion criteria
- Participants enrolled in Detroit Research on Cancer Survivors (Detroit ROCS)
- Diagnosis of Primary Breast, prostate, or colorectal cancer on or after 1/1/2013
- have received or currently receiving care at Karmanos Cancer Institute
- meet one or more of the National Comprehensive Cancer Network (NCCN) guidelines for cancer genetic testing as described below
Female breast
- personal diagnosis at age ≤50
- personal history of the triple-negative subtype
- at least 1 close (first- or second-degree) relative diagnosed with breast cancer at age <50
- at least 1 close relative diagnosed with ovarian cancer
- 2+ close relatives diagnosed with breast or prostate cancer
- age <50 AND another primary breast cancer at any age
- 2+ primary breast cancers at any age
OR Prostate
- personal history of high-risk or very high-risk prostate cancer
- personal history of regional or metastatic prostate cancer
- personal history of less than high-risk prostate cancer with a suggestive family history (i.e., father or brother or multiple relatives with prostate cancer diagnosed at age <60; at least 1 relative with breast, ovarian, or pancreatic cancer; or at least 1 relative with colorectal, ovarian, pancreatic, or kidney cancer)
OR Colorectal
- personal diagnosis at age ≤50
- at least 1 close relative diagnosed with HNPCC at age <50
- at least 2 close relatives diagnosed with an HNPCC cancer at any age
- colorectal and >=1 primary endometrial, ovarian, gastric, pancreatic, or prostate
Exclusion criteria
- Previous genetic counseling and/or testing
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Health services research
Study locations
United States · 1 center
- Karmanos Cancer Institute — Detroit
Identifiers
NCT: NCT07436078 · 2025-022 · 1P01CA272239-01A1