Culturally Adapting an Intervention to Increase Genetic Testing in African American Cancer Survivors

Официальное название

A Community-Engaged Approach to Culturally Adapting an Intervention to Increase Uptake of Genetic Testing Among African American Cancer Survivors

Обзор

The goal of this clinical trial is to culturally adapt an educational genetic counseling intervention to increase the uptake in genetic counseling and testing among African Americans at risk for heredity cancers. With the help of community stakeholders and clinical genetic professionals the investigators will: * adapt and refine a culturally relevant online educational genetic counseling program for at-risk African Americans * Test the effects of the educational program * collaborate with community leaders and clinical genetic professionals to translate study findings, develop a road map for dissemination to the community, and identify barriers to prepare for future trials. Participants from Detroit Research on Cancer Survivor group will be offered enrollment. Once consent is obtained, questionnaires will be completed before an online genetic counselling intervention immediately after, and at 3 months

Вмешательства

• Поведенческое Culturally adapted Online Genetic Counseling and Testing Information
  Testing the effects of the educational intervention designed to increase the uptake of genetic counseling testing among at-risk African American survivors

Первичные конечные точки

• Uptake of genetic counseling and genetic testing [Срок оценки: 3 month follow Up]

Вторичные конечные точки (12)

• Intention to undergo genetic counseling and testing [Срок оценки: 1 day Pre Intervention to 1 day Post Intervention]
• Sharing Your Results [Срок оценки: 3 month follow up]
• Major Experiences of Discrimination [Срок оценки: 1 day prior to intervention]
• Everyday Experiences of Discrimination [Срок оценки: 1 day prior to intervention]
• Interpersonal Processes of Care Survey [Срок оценки: 1 day prior to intervention]
• Group-Based Medical Mistrust Scale [Срок оценки: 1 day prior to intervention]
• Perceived Access to Health Care Services [Срок оценки: 1 day prior to intervention]
• Perceived risk of carrying genetic mutation [Срок оценки: 1 day Pre Intervention to 1 day Post Intervention]
• Attitudes about genetic counseling and testing [Срок оценки: 1 day Pre Intervention to 1 day Post Intervention]
• Behavioral beliefs about genetic counseling [Срок оценки: 1 day Pre Intervention to 1 day Post Intervention]
• Perceived norms [Срок оценки: 1 day Pre Intervention to 1 day Post Intervention]
• Knowledge of Genetic Counseling [Срок оценки: 1 day Pre Intervention to 1 day Post Intervention]

Критерии участия

Критерии включения

• Participants enrolled in Detroit Research on Cancer Survivors (Detroit ROCS)
• Diagnosis of Primary Breast, prostate, or colorectal cancer on or after 1/1/2013
• have received or currently receiving care at Karmanos Cancer Institute
• meet one or more of the National Comprehensive Cancer Network (NCCN) guidelines for cancer genetic testing as described below

Female breast

• personal diagnosis at age ≤50
• personal history of the triple-negative subtype
• at least 1 close (first- or second-degree) relative diagnosed with breast cancer at age <50
• at least 1 close relative diagnosed with ovarian cancer
• 2+ close relatives diagnosed with breast or prostate cancer
• age <50 AND another primary breast cancer at any age
• 2+ primary breast cancers at any age

OR Prostate

• personal history of high-risk or very high-risk prostate cancer
• personal history of regional or metastatic prostate cancer
• personal history of less than high-risk prostate cancer with a suggestive family history (i.e., father or brother or multiple relatives with prostate cancer diagnosed at age <60; at least 1 relative with breast, ovarian, or pancreatic cancer; or at least 1 relative with colorectal, ovarian, pancreatic, or kidney cancer)

OR Colorectal

• personal diagnosis at age ≤50
• at least 1 close relative diagnosed with HNPCC at age <50
• at least 2 close relatives diagnosed with an HNPCC cancer at any age
• colorectal and >=1 primary endometrial, ovarian, gastric, pancreatic, or prostate

Критерии исключения

• Previous genetic counseling and/or testing

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Организация здравоохранения

Центры проведения

США · 1 центр

• Karmanos Cancer Institute — Detroit

Идентификаторы

NCT: NCT07436078 · 2025-022 · 1P01CA272239-01A1

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗