Advanced Endoscopic Resections for Rectal Neoplasms
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Endoscopic submucosal dissection, Endoscopic intramuscular dissection.
- Who it may be relevant to
- Registry conditions: Rectal Cancer, Rectal Adenocarcinoma, Rectal Adenoma, Rectal Neuroendocrine Neoplasm. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Poland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Adoption of Advanced Endoscopic Resection Methods in the Treatment of Rectal Neoplasms
Overview
This study evaluates how advanced endoscopic resection techniques affect treatment outcomes in adults with rectal cancer. Rectal cancer has traditionally been treated with standard abdominal surgery. Newer endoscopic techniques allow removal of selected early tumors and may reduce treatment-related complications. However, their effectiveness and safety in tumors with deeper invasion are not yet fully established. This multicenter retrospective observational study uses existing medical records from adults who underwent endoscopic or surgical resection of rectal tumors between 2015 and 2025. Researchers will analyze anonymized information on procedures performed and treatment outcomes to assess the safety and effectiveness of advanced endoscopic approaches. The results of this study may help guide treatment selection and improve care for people with rectal cancer.
Interventions
- Procedure Endoscopic submucosal dissection
Endoscopic submucosal dissection is an advanced endoscopic technique used to remove rectal tumors in one piece through the endoscope. A circumferential incision is then made in the mucosa, followed by careful dissection within the submucosal layer until the lesion is completely removed. This technique enables precise pathological assessment of tumor margins and depth of invasion and is typically used for lesions suspected to have superficial submucosal invasion without clear evidence of lymph no - Procedure Endoscopic intramuscular dissection
Endoscopic intermuscular dissection is an advanced endoscopic resection technique designed for rectal tumors with suspected deeper submucosal invasion. Following mucosal incision, the dissection is intentionally performed in the plane between the inner circular and outer longitudinal muscle layers of the rectal wall. This allows deeper en bloc tumor removal compared with conventional endoscopic submucosal dissection. The goal of this technique is to achieve complete resection while potentially a
Primary outcome measures
- Major intraprocedural bleeding rate [Time frame: During the procedure]
- Intraprocedural perforation rate [Time frame: During the procedure]
- Delayed bleeding rate [Time frame: Within 28 days after the procedure]
- Delayed perforation rate [Time frame: Within 14 days after the procedure]
- Post-coagulation syndrome rate [Time frame: Within 28 days following the procedure]
- The need for emergency interventions [Time frame: Within 30 days after the procedure]
- Procedure-related mortality rate [Time frame: Within 30 days after the procedure]
Secondary outcome measures (5)
- En bloc resection rate [Time frame: Intraprocedural]
- Complete resection rate [Time frame: Within 30 days after the procedure]
- Procedure time [Time frame: Intraprocedural]
- Length of hospital stay [Time frame: Within 30 days after the procedure]
- The need for additional treatment [Time frame: Within 12 months after the procedure]
Eligibility criteria
Inclusion criteria
- Patients with rectal neoplasms treated by advanced endoscopic resection
Exclusion criteria
- hybrid resection performed
- full-thickness resection performed
- essential procedural or outcome data were unavailable
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Poland · 1 center
- Jagiellonian University in Krakow — Krakow
Identifiers
NCT: NCT07410767 · 1072.6120.2.63.2026