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Recruiting NCT07401797

Specimens for Lung Cancer Panel Design

— Observational Lung Nodules

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Lung Nodules. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

This is an observational study designed to determine the optimal combination of biomarkers and clinical data for the early detection, confirmation, and better treatment of lung cancer including minimizing recurrence.

Detailed description

Peripheral venous blood and clinical data will be collected from consented subjects with lung nodules identified in radiology that are suspicious for lung cancer before invasive diagnosis or treatment is initiated. Various analyses will be conducted to determine which subset of biomarkers is most likely to be the most useful in the clinic. Attributes considered are accuracy (sensitivity, specificity, improvement over other methods) and ease of collection and transport. Results will not be reported to treating physicians and will not alter care of the patient.

Primary outcome measures

  • Test performance [Time frame: Two years from final case enrollment]

Eligibility criteria

6.1 Criteria for the no prior cancer suspicious nodule arm

Inclusion:

  • The patient has at least one indeterminant nodule with a diameter greater than or equal to 5mm and a Mayo SPN risk greater than 5%, identified by radiology, that has not been biopsied or undergone surgery.
  • The patient and the treating physician intend to follow up on the nodule with a biopsy procedure, PET scan, or active surveillance, with the procedure or next surveillance planned within the next 7 months.
  • Ability to understand the study and sign an informed consent form
  • Relevant clinical data accessible
  • Ability and willingness to safely donate 40 mL of blood
  • Ability of the site to collect and process blood per protocol Exclusion

1\. The patient has one or more nodules with a Mayo SPN risk over 50% or a diameter of 30mm or greater.

2\. The patient has received surgical prep, including antibiotics, anesthesia, etc. Fasting is not exclusionary.

3\. Previous cancer diagnosis of any origin. 4. Is currently pregnant 5. Is currently a prisoner or becomes a prisoner at any point during the study 6. Is under age 18, is unable to consent, or requires a different person or entity to consent on their behalf 6.2 Criteria for the previous cancer suspicious nodule arm

Inclusion:

1\. The patient has at least one indeterminant nodule with a diameter greater than or equal to 5mm and a Mayo SPN risk greater than 5%, identified by radiology, that has not been biopsied or undergone surgery.

2\. The patient and the treating physician intend to follow up on the nodule with a biopsy procedure, PET scan, or active surveillance, with the procedure or next surveillance planned within the next 7 months.

3\. The patient has been in remission for a previous cancer not of lung origin for more than 5 years.

4\. Ability to understand the study and sign an informed consent form 5. Relevant clinical data accessible 6. Ability and willingness to safely donate 40 mL of blood 7. Ability of the site to collect and process blood per protocol Exclusion

  • The patient has one or more nodules with a Mayo SPN risk over 50% or a diameter of 30mm or greater.
  • The patient has received surgical prep, including antibiotics, anesthesia, etc. Fasting is not exclusionary.
  • Previous cancer diagnosis in the lung (either of lung origin or metastasis to the lung).
  • The treating physician believes the lung nodule is a recurrence of a previously diagnosed cancer.
  • Is currently pregnant
  • Is currently a prisoner or becomes a prisoner at any point during the study
  • Is under age 18, is unable to consent, or requires a different person or entity to consent on their behalf

6.3 Criteria for the healthy volunteer arm

Inclusion:

  • Ability to understand the study and sign an informed consent form
  • Relevant clinical data accessible
  • Ability and willingness to safely donate up to 40 mL of blood
  • The ability of the site to collect and process blood per protocol Exclusion

1\. Is currently pregnant 2. Is currently a prisoner or becomes a prisoner at any point during the study 3. Is under age 18, is unable to consent, or requires a different person or entity to consent on their behalf

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

United States · 1 center
  • Maverix Medical — Phoenix

Identifiers

NCT: NCT07401797 · MXDX008

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗