Lung Recruitment Assessed by 2D/3D-EIT and R/I Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: The lung recruitment potential assessed and PEEP titration by ventilator and 2D/3D EIT.
- Who it may be relevant to
- Registry conditions: Acute Respiratory Failure (ARF). Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Lung Recruitment Assessed by Two-Dimensional/Three-Dimensional Electrical Impedance Tomography and Recruitment-to-Inflation Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation
Overview
The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R/I ratio) and three-dimensional electrical impedance tomography (3D-EIT) and two-dimensional EIT (2D-EIT) in mechanically ventilated patients with acute respiratory failure. The main questions it aims to answer is: Are the lung recruitment potentials predicted by 3D-EIT, 2D-EIT and the R/I ratio consistent? Participants will: Undergo a standardized PEEP titration protocol with synchronized EIT monitoring; Have R/I ratios measured at high and low PEEP levels.
Interventions
- Diagnostic test The lung recruitment potential assessed and PEEP titration by ventilator and 2D/3D EIT
The patient will undergo a standardized PEEP titration procedure and determination of the Recruitment-to-Inflation ratio (R/I ratio), with concurrent monitoring by both 2D- and 3D- EIT.
Primary outcome measures
- Lung recruitment assessed by R/I ratio and 2D/3D-EIT （PEEP titration） [Time frame: Within 24 hours post-enrollment]
Eligibility criteria
Inclusion criteria
- Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing.
- Oxygenation index < 300 mmHg.
- Patients who are clinically judged by the attending doctor to require the PEEP titration.
Exclusion criteria
- Aged under 18 years.
- Pregnancy.
- Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others).
- No informed consent obtained.
- Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor.
- High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
China · 1 center
- Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union — Beijing
Identifiers
NCT: NCT07379242 · 3D EIT-based PEEP & R/I ratio