Efficacy of Ultrasound Guided Erector Spinae Plane Block Versus Ultrasound Guided Serratus Anterior Plane Block for Postoperative Pain Control Following Video-assisted Thoracoscopic Surgeries (VATS): Randomized Control Trial
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In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Erector Spinae (ESP) Block with Bupivacaine (Marcaine®), Serratus anterior plane block (SAP).
- Who it may be relevant to
- Registry conditions: Post Operative Pain Control. Basic parameters: 25 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The aim of the study is to compare the analgesic efficacy of Erector spinae plane block versus Serratus anterior plane block in patients undergoing video-assisted thoracoscopic surgeries.
Detailed description
The aim of the study is to compare the analgesic efficacy of Erector spinae plane block versus Serratus anterior plane block in patients undergoing video-assisted thoracoscopic surgeries.
Preoperative: - On the day before surgery, all patients will be evaluated, detailed medical and surgical history will be taken also physical and systemic examinations will be done.
The following investigations will be done including complete blood count, liver enzymes, prothrombin time, partial thromboplastin time, International normalized ratio (INR) , kidney functions, serum electrolytes and ECG.
All patients will be informed about the visual analogue scale (VAS) on a scale from 0 to 10 where 0 represents no pain and 10 represents the worst imaginable pain.
In the pre-Anesthetic room:
* baseline hemodynamics will be recorded including heart rate (HR) and mean arterial blood pressure (MAP) and An intravenous access will be inserted. * In the operating theatre, full monitors will be applied. Intraoperative: - * Fentanyl (1 μg/kg), propofol (2 mg/kg) and atracurium(0.5 mg/kg) will be given IV for general anesthesia induction. * Intubation will be done using a double-lumen endobronchial tube size 37 Fr in females and 39 Fr in males, tidal volume will be 6-8 ml/kg in case of both lungs ventilation and 4-6ml/kg during singe lung ventilation.
Anesthesia will continue using isoflurane 2 vol. %, 50% O2 and 50% air.
* Moreover, three milligrams of Granisetron will be given as prophylactic against nausea and vomiting post-operatively. * During operation, 6 mL/kg/h of Ringer's solution will be administered. * At the end of surgery, the patient will be positioned laterally. * All blocks will be done using ultrasound-guidance (Mindray ultrasound) using high frequency linear probe (10-12 MHZ) by the same experienced senior doctors.
Group A : (25 patients) patients will receive Erector Spinae Plane Block using 20 mL of 0.25% bupivacaine.
Group B: (25 patients) patients will recieve Serratus Aneterior Plane Block using 20 mL of 0.25% bupivacaine.
Interventions
- Procedure Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)
Ultrasound Guided Erector Spinae Plane block using 20 mL of 0.25% bupivacaine. - Procedure Serratus anterior plane block (SAP)
Ultrasound Guided Serratus Anterior Plane Block using 20 mL of 0.25% bupivacaine.
Primary outcome measures
- Visual analogue scale for Assessing postoperative pain control [Time frame: after ICU admission at 2, 4, 8, 16, 24 hours post operative.]
Eligibility criteria
Inclusion criteria
- Patients with American Society of Anesthesiology physical status ASA I, II and III.
- Patients aged between 25 and 70 years.
- patients undergoing video-assisted thoracoscopic surgeries (VATS), including pleurectomy, bullectomy, sympathectomy, esophagectomy, decortication, lobectomy, and pneumonectomy.
Exclusion criteria
- Patients below age of 25 or above age of 70.
- Patient refusal.
- Allergy to local anesthetic drugs.
- Bleeding or coagulation disorder.
- Psychiatric disorders.
- Infection at the needle entry site.
- Renal impairment (creatinine >1.5 ).
- Hepatic impairment (Child B or C).
- Patients with known Cortisol related diseases such as Cushing's Syndrome or Addison's Disease.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Ain-Shams University Hospitals — Cairo
Identifiers
NCT: NCT07360028 · FMASU MD 307/2025