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Not yet recruiting NCT07359495

Multicomponent Training and Muscle Quality in Older Women

No phase Interventional Sarcopenia

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Multicomponent training.
Who it may be relevant to
Registry conditions: Sarcopenia. Basic parameters: from 60 years · Female.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Spain
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Effect of a Multicomponent Exercise Program on Muscle Quality Assessed by Ultrasound, Body Composition, and Functionality in Older Women: A Randomized Controlled Trial Protocol

Overview

This study aims to evlauate the effect os a 32-week multicomponent training (MT) program on muscle architecture and muscle quality (assessed by ultrasound) in womer over 60 years. The study will also analyze concurrent changes in muscle strength, physical performance, and body composition. The hypothesis is that the training will induce positive architectural adaptations, such as reduced echogenicity and increased thickness in the rectus femoris and rectus abdominis muscles, correlating with improved functional independence.

Detailed description

Population aging emphasizes the need for "healthy aging", where muscle quality (MQ) is a vital metric. However, there is a lack of robust longitudinal protocols integrating ultrasound-assessed MQ with functional performance in older women. This randomized controlled trial involves community-dwelling women aged 60+ from the Geriatric Revitalization Program in Salamanca. Participants will be randomized (1:1) into an experimental group (multicomponent training) or a control group. The intervention is a 32-week supervised program (3 sessions/week, 50 min/session) combining aerobic, strength, balance, and coordination exercises. Primary outcomes focus on muscle architecture (echo intensity and thickness) in the rectus femoris and rectus abdominis muscles. Secondary outcomes include functional capacity (SPPB, TUG, 5-time sit-to-stand), handgrip strength, and body composition.

Interventions

  • Other Multicomponent training
    The exercise battery includes lower body work (squats, deadlifts, front and sagittal plane lunges, hip abduction/extension, and plantar flexion) and upper body work (wall flexion-extensions, shoulder raises, and elbow flexion-extensions). In addition to the strength exercises mentioned above, balance exercises such as walking in tandem, standing on one leg, side steps, and weight transfer will also be performed. Aerobic capacity will be worked on by walking at a moderate intensity, and flexibili

Primary outcome measures

  • Echo intensity [Time frame: Baseline and 32 weeks]
  • Muscle thickness (mm) [Time frame: Baseline and 32 weeks]
  • Cross-sectional area [Time frame: Baseline and 32 weeks]
  • Subcutaneous adipose tissue thickness [Time frame: Baseline and 32 weeks]
Secondary outcome measures (8)
  • Handgrip strength (kg) [Time frame: Baseline and 32 weeks]
  • Short Physical Performance Battery (SPPB) [Time frame: Baseline and 32 weeks]
  • Timed Up and Go (TUG) [Time frame: Baseline and 32 weeks]
  • 5-time sit-to-stand (5STS) [Time frame: Baseline and 32 weeks]
  • Body Mass Index (BMI) [Time frame: Baseline and 32 weeks]
  • Body Fat Percentage [Time frame: Baseline and 32 weeks]
  • Abdominal Circumference [Time frame: Baseline and 32 weeks]
  • Waist-to-Hip Ratio [Time frame: Baseline and 32 weeks.]

Eligibility criteria

Inclusion criteria

  • Being a woman over 60 years of age, residing in the community, and enrolled in the GPR

Exclusion criteria

  • Having neuromuscular diseases, recent abdominal surgery, metal implants incompatible with measurements, unstable cardiovascular diseases, or previous participation in another exercise program.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

Spain · 1 center
  • University of Salamanca — Salamanca

Identifiers

NCT: NCT07359495 · USalamancaMTUS

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗