Preoperative Neutrophil-to-Lymphocyte Ratio and Early Postoperative Pain After Septorhinoplasty
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Observational Study.
- Who it may be relevant to
- Registry conditions: Neutrophil-to-Lymphocyte Ratio, Septorhinoplasty. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Relationship Between Preoperative Neutrophil-to-Lymphocyte Ratio and Hemogram Parameters and Early Postoperative Pain Scores in Patients Undergoing Septorhinoplasty
Overview
This prospective, observational study investigates the relationship between early oxygen exposure and oxidative stress in adult intensive care unit patients with sepsis or septic shock. Fraction of inspired oxygen (FiO₂) administered during the first 24 hours of ICU admission will be recorded and analyzed in relation to changes in the uric acid/albumin ratio (UAR), a biomarker reflecting oxidative burden and inflammation. Serum uric acid and albumin levels will be measured at baseline and at 24 hours, and the percentage change in UAR will be calculated. Secondary analyses will examine associations between UAR changes, oxygenation indices, and 28-day mortality. The study aims to determine whether higher FiO₂ exposure is associated with increased oxidative stress and to evaluate the potential role of UAR as a clinically accessible marker of oxygen-related oxidative injury in septic ICU patients.
Interventions
- Other Observational Study
Not applicable. This is a prospective observational study. No intervention or alteration to standard treatment protocols will be performed. Clinical and laboratory data obtained during routine care, including preoperative hemogram parameters and early postoperative pain scores, will be recorded and analyzed without influencing patient management.
Primary outcome measures
- Early Postoperative Pain Severity [Time frame: Within the first 60 minutes after admission to the Post-Anesthesia Care Unit (PACU).]
Eligibility criteria
Inclusion criteria
- Adult patients aged 18-65 years
- Patients undergoing elective septorhinoplasty
- Surgery performed under general anesthesia
- Complete recording of early postoperative VAS pain scores, Aldrete scores, NUDES scores, and vital signs in the Post-Anesthesia Care Unit (PACU)
- Preoperative complete blood count (hemogram) performed within 30 days prior to surgery
- Clinical records and hospital information system data that are complete, accessible, and adequate for analysis
Exclusion criteria
- Patients undergoing emergency surgery
- Septorhinoplasty combined with additional major surgical procedures (e.g., advanced ENT or maxillofacial surgery)
- Presence of known hematological disease, active infection, immunosuppressive therapy, or advanced liver or renal failure
- Chronic opioid use or regular analgesic medication use in the preoperative period
- History of significant clinical events between the preoperative hemogram and surgery that could alter inflammatory status (e.g., infection, hospitalization, additional surgery)
- Incomplete or missing data regarding preoperative hemogram parameters or PACU pain scores
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Publications
- Sachidananda R, Malipatil A, Joshi V, Hosamani A, Haranagatti A, Kurugodiyavar MD. Relationship between neutrophil-lymphocyte ratio and postoperative pain in cesarean section patients done under subarachnoid block: A prospective observational study. J Anaesthesiol Clin Pharmacol. 2025 Jul-Sep;41(3):464-469. doi: 10.4103/joacp.joacp_213_24. Epub 2024 Dec 16. PMID 40635819
- Yildiz Altun A, Demirel I, Bolat E, Ozcan S, Altun S, Aksu A, Bestas A. The Relationship Between the Preoperative Neutrophil-to-Lymphocyte Ratio and Postoperative Nausea and Vomiting in Patients Undergoing Septorhinoplasty Surgery. Aesthetic Plast Surg. 2019 Jun;43(3):861-865. doi: 10.1007/s00266-019-01325-5. Epub 2019 Feb 14. PMID 30767038
Identifiers
NCT: NCT07353138 · 323-2025