Preoperative Neutrophil-to-Lymphocyte Ratio and Early Postoperative Pain After Septorhinoplasty
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Observational Study.
- Кому может быть актуально
- Состояния в реестре: Neutrophil-to-Lymphocyte Ratio, Septorhinoplasty. Базовые параметры: 18 лет — 65 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Список центров уточняется — проверьте первичный протокол.
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
Не всё понятно в терминах? Прочитайте наш гид для пациентов →
Официальное название
The Relationship Between Preoperative Neutrophil-to-Lymphocyte Ratio and Hemogram Parameters and Early Postoperative Pain Scores in Patients Undergoing Septorhinoplasty
Обзор
This prospective, observational study investigates the relationship between early oxygen exposure and oxidative stress in adult intensive care unit patients with sepsis or septic shock. Fraction of inspired oxygen (FiO₂) administered during the first 24 hours of ICU admission will be recorded and analyzed in relation to changes in the uric acid/albumin ratio (UAR), a biomarker reflecting oxidative burden and inflammation. Serum uric acid and albumin levels will be measured at baseline and at 24 hours, and the percentage change in UAR will be calculated. Secondary analyses will examine associations between UAR changes, oxygenation indices, and 28-day mortality. The study aims to determine whether higher FiO₂ exposure is associated with increased oxidative stress and to evaluate the potential role of UAR as a clinically accessible marker of oxygen-related oxidative injury in septic ICU patients.
Вмешательства
- Другое Observational Study
Not applicable. This is a prospective observational study. No intervention or alteration to standard treatment protocols will be performed. Clinical and laboratory data obtained during routine care, including preoperative hemogram parameters and early postoperative pain scores, will be recorded and analyzed without influencing patient management.
Первичные конечные точки
- Early Postoperative Pain Severity [Срок оценки: Within the first 60 minutes after admission to the Post-Anesthesia Care Unit (PACU).]
Критерии участия
Критерии включения
- Adult patients aged 18-65 years
- Patients undergoing elective septorhinoplasty
- Surgery performed under general anesthesia
- Complete recording of early postoperative VAS pain scores, Aldrete scores, NUDES scores, and vital signs in the Post-Anesthesia Care Unit (PACU)
- Preoperative complete blood count (hemogram) performed within 30 days prior to surgery
- Clinical records and hospital information system data that are complete, accessible, and adequate for analysis
Критерии исключения
- Patients undergoing emergency surgery
- Septorhinoplasty combined with additional major surgical procedures (e.g., advanced ENT or maxillofacial surgery)
- Presence of known hematological disease, active infection, immunosuppressive therapy, or advanced liver or renal failure
- Chronic opioid use or regular analgesic medication use in the preoperative period
- History of significant clinical events between the preoperative hemogram and surgery that could alter inflammatory status (e.g., infection, hospitalization, additional surgery)
- Incomplete or missing data regarding preoperative hemogram parameters or PACU pain scores
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Список центров уточняется — проверьте первичный протокол.
Публикации
- Sachidananda R, Malipatil A, Joshi V, Hosamani A, Haranagatti A, Kurugodiyavar MD. Relationship between neutrophil-lymphocyte ratio and postoperative pain in cesarean section patients done under subarachnoid block: A prospective observational study. J Anaesthesiol Clin Pharmacol. 2025 Jul-Sep;41(3):464-469. doi: 10.4103/joacp.joacp_213_24. Epub 2024 Dec 16. PMID 40635819
- Yildiz Altun A, Demirel I, Bolat E, Ozcan S, Altun S, Aksu A, Bestas A. The Relationship Between the Preoperative Neutrophil-to-Lymphocyte Ratio and Postoperative Nausea and Vomiting in Patients Undergoing Septorhinoplasty Surgery. Aesthetic Plast Surg. 2019 Jun;43(3):861-865. doi: 10.1007/s00266-019-01325-5. Epub 2019 Feb 14. PMID 30767038
Идентификаторы
NCT: NCT07353138 · 323-2025