Combined High-Intensity Aerobic Training and Resistance Training in Psoriatic Arthritis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Exercise program.
- Who it may be relevant to
- Registry conditions: Psoriatic Arthritis. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Sweden
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Effects of Combined High-Intensity Aerobic Training and Resistance Training on Cardiovascular and Metabolic Health in Psoriatic Arthritis
Overview
The goal of this randomised controlled trial is to evaluate the effects of a 12-week intervention comprising high-intensity interval aerobic training and strength training on cardiovascular function, metabolic health profile and inflammation in patients with Psoriatic arthritis. A secondary goal is to assess the intervention´s impact on physical fitness, pain, fatigue, and health-related quality of life, and to explore long-term maintenance of exercise following completion of the intervention. We hypothesize that 12 weeks of combined high-intensity interval aerobic training and strength training will improve cardiometabolic health, inflammation, and enhance physical fitness, fatigue, pain and quality of life in Psoriatic arthritis.
Interventions
- Behavioral Exercise program
The exercise program includes two supervised sessions per week combining high-intensity interval training and strength training, plus one additional non-supervised aerobic session. The target of the high intensity intervals is 90%-95% of heart rate maximum. The strength training of major muscle groups includes 2-3 sets of 8-10 repetitions.
Primary outcome measures
- Cardiopulmonary function [Time frame: Baseline and 3 month]
- Cardiopulmonary function [Time frame: Baseline and 9 month]
Secondary outcome measures (12)
- Waist circumference [Time frame: Baseline and 3 months]
- Waist circumference [Time frame: Baseline and 9 months]
- Body mass index (BMI) [Time frame: Baseline and 3 months]
- Body mass index (BMI) [Time frame: Baseline and 9 months]
- Body composition [Time frame: Baseline and 3 months]
- Body composition [Time frame: Baseline and 9 months]
- Triglycerides [Time frame: Baseline and 3 months]
- Triglycerides [Time frame: Baseline and 9 months]
- High-density lipoprotein cholesterol (HDL-C) [Time frame: Baseline and 3 months]
- High-density lipoprotein cholesterol (HDL-C) [Time frame: Baseline and 9 months]
- Low-density lipoprotein cholesterol (LDL-C) [Time frame: Baseline and 3 months]
- Low-density lipoprotein cholesterol (LDL-C) [Time frame: Baseline and 9 months]
Eligibility criteria
Inclusion criteria
- Psoriatic arthritis disease according to the CASPAR (Classification Criteria for Psoriatic Arthritis) criteria
- Age range 18-65 years
- Stable medication on anti- rheumatic drugs for >3 months prior to inclusion and throughout the first 3 months of the study
Exclusion criteria
- Cardiovascular disease
- Severe hypertension
- Diabetes type I
- Chronic obstructive pulmonary disease or other severe pulmonary diseases
- Arthroplasty of large joints, lower extremities
- Severe functional impairment precluding participation in high-intensity aerobic exercise
- Inability to perform a cardiopulmonary exercise testing (CPET)
- Pregnancy
- BMI ≥35 kg/m²
- Ongoing or planned initiation (within 3 months) of structured weight reduction therapy, pharmacological obesity treatment, or bariatric bypass surgery
- Already participating in regular exercise at high intensity (BORG ≥15) for >1 hour/ week during the past 6 months
- Inability to understand and read Swedish
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Sweden · 2 centers
- Sahlgrenska University hospital — Gothenburg
- Skaraborgs sjukvård, Skövde — Skövde
Identifiers
NCT: NCT07352696 · Vastra Gotaland record 286312