Clindamycin as Antimicrobial Treatment for Streptococcus Spp. PeRiprosthetic Infection
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Streptococcus Infection. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Clindamycin is an antibiotic with several advantages: high oral bioavailability and good bone and joint penetration. In France, it is a recommended drug for other types of Streptococcus spp. osteoarticular infections and can be used as an alternative to amoxicillin for periprosthetic infections, including when implants are retained. The hypothesis of this study is that clindamycin is no less effective than other drugs commonly used to treat periprosthetic Streptococcus spp. infections. The primary objective of this study is to evaluate the success rate of Streptococcus spp. periprosthetic joint infections treated with clindamycin compared to other antibiotic treatments.
Primary outcome measures
- Therapeutic success of the medical-surgical strategy [Time frame: One year after the end of antibiotic treatment]
Eligibility criteria
Inclusion criteria
- Adult patient (aged 18 years or older) at the time of surgery for infection
- Probable or proven periprosthetic infection with Streptococcus spp. according to EBJIS diagnostic criteria
- Patient operated on in one of the associated centers between 2013 and 2024
Exclusion criteria
- Patient who underwent joint resection or amputation
- Patient who was treated with suppressive antibiotic therapy (defined as antibiotic treatment lasting more than 6 months) which was decided upon prior to surgery
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
France · 1 center
- Service de Chirurgie Orthopédique Septique - CHU de Strasbourg - France — Strasbourg
Identifiers
NCT: NCT07335627 · 9536