Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Intraoperative Oxygenation and Pulmonary Mechanics. Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effects of Magnesium Sulfate on Intraoperative Oxygenation and Lung Mechanics During One-Lung Ventilation: A Prospective Observational Study
Overview
This prospective observational study aims to evaluate the effects of intravenous magnesium sulfate on intraoperative oxygenation and lung mechanics in patients undergoing thoracic surgery with one-lung ventilation. Magnesium sulfate has been reported to have potential bronchodilatory and anti-inflammatory properties, which may improve gas exchange and respiratory mechanics during lung isolation. In this study, patients who receive magnesium sulfate as part of standard anesthetic management will be compared with those who do not receive the drug. Oxygenation parameters, dynamic and static lung mechanics, airway pressures, and ventilation-related indices will be recorded throughout the intraoperative period. The findings of this study may help clarify whether magnesium sulfate provides measurable respiratory benefits during one-lung ventilation.
Primary outcome measures
- Change in Intraoperative Oxygenation (PaO₂/FiO₂ Ratio) [Time frame: From induction of anesthesia to the end of one-lung ventilation (approximately 2-3 hours)]
Secondary outcome measures (3)
- Changes in Airway Pressures (Peak and Plateau Pressures) [Time frame: From induction of anesthesia to the end of one-lung ventilation (approximately 2-3 hours).]
- Dynamic Lung Compliance and Airway Resistance (Raw) [Time frame: Intraoperative period (approximately 2-3 hours).]
- Postoperative Arterial Oxygen Partial Pressure (PaO₂) on Room Air [Time frame: Within the first postoperative hour while breathing room air.]
Eligibility criteria
Inclusion criteria
Adults aged 18 to 80 years Scheduled for elective thoracic surgery performed with video-assisted thoracoscopic surgery (VATS) requiring one-lung ventilation under general anesthesia.
ASA physical status II-III Ability to provide informed consent Undergoing general anesthesia with double-lumen tube placement
Exclusion criteria
- Patients undergoing pneumonectomy
- Patients with renal, hepatic, or cardiovascular failure
- Patients with a BMI < 15 kg/m² or > 35 kg/m²
- Patients with a preoperative pulmonary function test showing FEV₁ < 1.5 liters
- Patients who are transferred to the intensive care unit intubated in the postoperative period
- Patients with physical or mental conditions that prevent the performance of pulmonary function testing factors
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Turkey (Türkiye) · 1 center
- Marmara University Faculty of Medicine, Basibuyuk Campus — Istanbul
Identifiers
NCT: NCT07325773 · 09.2025.463