Long-term Evaluation of Fertility Preservation Options in Women in Cancer Remission or Haematological Pathology
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Fertility Preservation, Cancer Remission, Reproductive Outcomes, Reproductive Health. Basic parameters: 18 years — 47 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Cancer treatments, despite their increasing effectiveness, carry a significant risk of gamete toxicity. Women of reproductive age are commonly offered fertility preservation (FP) before starting their treatment. However, few studies have analyzed the long-term reproductive outcomes of these interventions, nor how patients ultimately use or do not use the FP options once in remission. This project aims to better understand the effectiveness, utilization, and psychological impacts of these strategies. This work is part of an effort to understand and evaluate fertility preservation practices implemented for women of reproductive age undergoing cancer treatment at the Amiens-Picardie University Hospital (CHU). Its objective is to document patient pathways, clinical decisions, techniques employed, and reproductive outcomes observed after remission, in order to identify potential areas for improvement in the support and follow-up of these patients, thereby enhancing the overall quality and coordination of care. This work is conducted alongside the development of a fertility observatory at the Department of Medicine and Reproductive Biology, CHU Amiens-Picardie.
Primary outcome measures
- Occurrence of an identifiable reproductive outcome [Time frame: 1 year]
Secondary outcome measures (11)
- Type of fertility preservation method performed [Time frame: 1 year]
- Time interval (in months) between diagnosis and fertility preservation [Time frame: 1 year]
- Correlation between Age and occurance of an identifiable reproductive outcome [Time frame: 1 year]
- Time interval (in months) between fertility preservation and initiation of potentially gonadotoxic treatment [Time frame: 1 year]
- Number of type of cancer associated with identifiable reproductive outcome [Time frame: 1 year]
- Correlation between type of treatment and occurence of an identifiable reproductive outcome [Time frame: 1 year]
- Correlation between family status and occurence of an identifiable reproductive outcome [Time frame: 1 year]
- Time interval (in months) between completion of treatment and pregnancy attempt (spontaneous or medically assisted) [Time frame: 1 year]
- Actual utilization rate of preserved material [Time frame: 1 year]
- Success rate of reuse attempts [Time frame: 1 year]
- Proportion of patients who ultimately did not pursue parenthood [Time frame: 1 year]
Eligibility criteria
Inclusion criteria
- Women
- Aged between 18 and 47 years
- Diagnosed with cancer or hematological disorders requiring potentially gonadotoxic treatment
- Having undergone a medical fertility preservation consultation
- Followed at Amiens Picardie University Hospital (CHU Amiens Picardie) in the department of Reproductive Medicine
- Currently in remission
- Having expressed non-opposition to participation in the study
Exclusion criteria
- Absence of remission
- Patients deprived of liberty by administrative or judicial decision, or placed under legal protection (guardianship or curators)
- Decline to participate in the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
France · 1 center
- CHU Amiens Picardie — Amiens
Identifiers
NCT: NCT07312058 · PI2025_843_0156