Halt Aging in Survivors of Blood Cancers
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Behavioral Coaching Intervention, Virtual Exercise Platform.
- Who it may be relevant to
- Registry conditions: Hematological Malignancy, Leukemia, Lymphoid Leukemia, Multiple Myeloma. Basic parameters: from 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Halt Aging in Survivors of Blood Cancers: the HALTAging-1 Study
Overview
Older survivors of blood cancer are at a high risk of accelerated biological aging, which increases their risk of developing multiple aging-related conditions. Whereas physical exercise can improve overall health, older cancer survivors do not meet the recommended physical activity, highlighting the need to develop behavioral interventions to increase adherence. Several other knowledge gaps exist to implement exercise interventions in older survivors of blood cancer; the dose and duration of exercise necessary to slow biological aging in older blood cancer survivors remain unknown. To bridge these gaps in knowledge, we have designed a Phase 2 randomized control trial to test the effects of behavioral and exercise interventions on various outcomes.
Interventions
- Behavioral Behavioral Coaching Intervention
Intervention arm incorporating virtually supervised moderate-intensity aerobic exercise and behavioral intervention/coaching to improve adherence - Behavioral Virtual Exercise Platform
Access to a virtual exercise platform that provides exercise classes and educational sessions for older survivors of blood cancer
Primary outcome measures
- Percentage of participants who adhered to the exercise regimen at 6-months post enrollment. [Time frame: 6 Months from start of program]
- Percentage of participants who adhered to the exercise regimen at 12-months post enrollment. [Time frame: 12 Months from start of program.]
Secondary outcome measures (1)
- Physical Function (6- Minute Walk Test Distance) [Time frame: 6 months from randomization]
Eligibility criteria
Inclusion criteria
- Age ≥50 years
- A history of hematological malignancy
- Participants must be able to and willingly give informed consent
Exclusion criteria
- Patients receiving intensive induction or consolidation chemotherapy. Maintenance chemotherapy, or lower-intensity chemotherapy for an indolent hematological malignancy is allowed.
- Neurodegenerative disease (e.g. Alzheimer's dementia), stroke, or uncontrolled psychotic disorders (e.g. schizophrenia or bipolar disorder) in the past 3 months if those disorders are considered significant enough to impair participation in the study.
- Illnesses such as clinical evidence of decompensated heart failure, unstable angina, or orthopedic or neuromuscular disorders that could limit safe participation in aerobic exercise.
- Cardiopulmonary exercise test results that preclude safe exercise (e.g., life-threatening arrhythmia, balance difficulties, peak VO2 <10 ml/kg/min).
- Estimated life expectancy of less than 6 months (that precludes assessment of study primary endpoint).
- Self-reported pregnancy or the possibility of pregnancy.
- Participants who do not plan to follow up at the participating center.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Supportive care
Study locations
United States · 1 center
- University of Nebraska Medical Center — Omaha
Identifiers
NCT: NCT07292272 · 606-25-FB