Clinico-Epidemiological Profile Of Acquired Aplastic Anemia Among Children At Assiut Governorate .
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: observational case series study no intervention.
- Who it may be relevant to
- Registry conditions: Acquired Aplastic Anaemia. Basic parameters: 1 year — 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Clinico_Epidemiological Profile Of Acquired Aplastic Anemia Among Children At Assiut Governorate.
Overview
1. Assessment the clinical presentation and epidemiological profile of children with acquired aplastic anemia. 2. Determining the possible risk factors and associated conditions contributing to the development of acquired aplastic anemia.
Detailed description
Aplastic anaemia is a term describing the common findings of pancytopenia and marrow hypoplasia from arising variety of disease states, including acquired aplastic anaemia and a variety of congenital marrow failure states(1). The global incidence of paediatric AA varies geographically, with rates of 2 to 3 cases per million per year in Europe, but higher in East Asia and certain developing regions(2) .Among Egyptian Children, inherited bone marrow failure syndromes (BMFS), including AA, constitute about 10-15%of all BMFS and up to 30% of paediatric BMFS ,with an average of 65 cases per million live births each year .Acquired AA remains the predominant from in older children and adolescent , while inherited forms are more common in younger children(3).The clinical presentation of aplastic anaemia regularly consists of symptoms associated with pancytopenia, including fatigue, pallor, bruising, bleeding, and extended susceptibility to infections(4). Identified etiologic risk factors include infections of viral origin, such as hepatitis-associated, Epstein-Barr, parvovirus, human immunodeficiency virus, varicella zoster, measles and other viruses, as well as exposure to toxic chemicals (e.g. benzene, pesticides and insecticides) and ionizing radiation (5). Over the last three decades, bone marrow transplantation (BMT) from a matched related donor (MRD) has been the treatment of choice for children with acquired AA (6) The Rationale of our study: aplastic anaemia in children is a serious ,life threatening bone marrow failure syndrome ,often resulting from immune-mediated destruction of hematopoietic stem cell triggered by factors such as viral infections, environmental toxin, or genetic predispositions and requires precise diagnosis to distinguish from inherited bone marrow failure syndromes or hypoplastic myelodysplastic syndrome to guide appropriate treatment strategies .
The Research question: What is the clinico-epidemiological profile of acquired aplastic anaemia among children at Assiut governorate.
Interventions
- Other observational case series study no intervention
Assessment the clinical presentation and epidemiological profile of children with acquired aplastic anemia. 2.Determining the possible risk factors and associated conditions contributing to the development of acquired aplastic anemia.
Primary outcome measures
- Acquired Aplastic Anemia among children [Time frame: from October 2020 to October 2026]
- determine the clinico-Epidemiological profile of acquired aplastic anemia among children at assuit governorate [Time frame: from october 2020 to october 2026]
Eligibility criteria
Inclusion criteria
- 1- Children aged 1-18 years old diagnosed with acquired aplastic anemia 2-Fulfillment of the diagnostic criteria for acquired AA 3-patient with complete medical records,including diagnostic ,labaratory and treatement data 4-Diagnosed or treated at assuit university children hospital and the central health insurance clinic at assuit Governorate (october 2020 to october 2026)
Exclusion criteria
- 1-children with congental bone marrow failure syndrome 2-patient with a history of chemotherapy or radiotherapy prior to diagnosis 2-cases with incomplete medical or insufficient medical records that prevented confirmination of diagnosis or extraction of essential study data
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07259863 · Aplastic anemia in children .