Hydrogen Peroxide and Ultraviolet Light for Disinfecting Surfaces in Intensive Care Units
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Aerosol of hydrogen peroxide, Irradiation of ultraviolet light.
- Who it may be relevant to
- Registry conditions: Infection, Hospital, Antimicrobial, Pneumonia Associated With Mechanical Ventilation, Urinary Tract Infection(UTI). Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Brazil
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Hydrogen Peroxide and Ultraviolet Light for Disinfecting Surfaces in Intensive Care Units: A Randomized, Controlled, Cluster, Crossover Clinical Trial
Overview
Healthcare-associated infections (HAIs) remain a major problem in intensive care units (ICUs), driven by environmental contamination with multidrug-resistant organisms that persist despite routine manual cleaning. While hydrogen peroxide aerosolization and ultraviolet-C light devices have shown promise in reducing surface contamination, current evidence is inconsistent, mostly derived from single-center studies, and rarely linked to patient-centered outcomes. The investigators will conduct this cluster-randomized, crossover trial in 12 Brazilian ICUs. Each ICU will sequentially implement three strategies: (1) usual surface disinfection; (2) usual surface disinfection followed by hydrogen peroxide aerosolization at 7.9% concentration, applied through a dedicated device inside a protective tent during terminal cleaning of patient beds; and (3) usual surface disinfection followed by automated ultraviolet-C irradiation, also applied under the same tent to shield adjacent occupied beds. The primary outcome will be the antimicrobial utilization, measured as daily defined doses (DDD) of antimicrobials at the ICU level per 100 patient-days, with secondary outcomes including HAI incidence rate, environmental contamination with multidrug-resistant organisms, specific HAIs incidence rate (associated-ventilator pneumonia, central-line associated bloodstream infection, and catheter-associated urinary tract infection), and ICU length of stay costs.
Interventions
- Other Aerosol of hydrogen peroxide
Spray of aerosolized peroxide hydrogen using a specific device when performing terminal cleaning of the ICU bed after the patient's discharge. - Other Irradiation of ultraviolet light
Irradiation of UV light for the purpose of disinfecting beds and surfaces near beds during terminal cleaning.
Primary outcome measures
- Antimicrobial utilization at the ICU level [Time frame: 3 months]
Secondary outcome measures (6)
- Healthcare-associated infections [Time frame: 3 months]
- Contamination of environmental surfaces by multi-resistant microorganisms [Time frame: 3 months]
- Incidence density of ventilator-associated pneumonia [Time frame: 3 months]
- Incidence density of central line-associated bloodstream infections [Time frame: 3 months]
- Incidence density of catheter-associated urinary tract infection [Time frame: 3 months]
- Intensive care unit length of stay costs [Time frame: 3 months]
Eligibility criteria
Inclusion criteria
- All patients aged 18 years and older who will be admitted to the participating ICUs
Exclusion criteria
- Patients under 18 years
- ICUs that use peroxide hydrogen or ultraviolet light for surface disinfection as part of their protocol
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Double blind
- Primary purpose
- Prevention
Study locations
Brazil · 12 centers
- Hospital Maternidade Sao Vicente De Paulo — Barbalha
- Instituto Hospital de Base — Brasília
- Hospital Estadual de Aparecida de Goiânia — Aparecida de Goiânia
- Santa Casa de Misericórdia de Passos — Passos
- Fundo Municipal de Saúde de Maringá — Maringá
- Hospital da Restauração — Recife
- Hospital Universitário da Universidade Federal do Piauí — Teresina
- Hospital Universitário Onofre Lopes — Natal
- … and 4 more centers
Identifiers
NCT: NCT07233837 · CAAE 71265723.0.1001.0071