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Enrolling by invitation NCT07226908

Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation

No phase Interventional Epilepsy

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Cognitive experiment, Electrical stimulation of the brain.
Who it may be relevant to
Registry conditions: Epilepsy. Basic parameters: 18 years — 65 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

The goal of the study is to examine how two key subregions of the human thalamus (ANT and PLV) are connected with other brain structures (Aim 1), how seizures involve the two thalamic subregions differently and how the map of cortico-thalamic ictal propagation matches the intrinsic connectivity maps identified in the same individuals (Aim 2), and the effect of ANT and PLV stimulations on memory formation (Aim 3).

Interventions

  • Other Cognitive experiment
    Record brain activity during memory encoding
  • Other Electrical stimulation of the brain
    Measure accuracy and reaction time during cognitive tasks

Primary outcome measures

  • Cerebro-cerebral evoked potentials [Time frame: During experiment up to 2 weeks]
  • fMRI BOLD activity [Time frame: During experiment up to 2 weeks]
  • Epileptogenicity Index (EI) [Time frame: During experiment up to 2 weeks]
  • Seizure propagation [Time frame: During experiment up to 2 weeks]
  • Coordinated activity across HPC and ANT [Time frame: During experiment up to 2 weeks]
  • Cognitive task performance [Time frame: During experiment up to 2 weeks]

Eligibility criteria

Inclusion criteria

  • No medical or surgical contraindication to electrode implantation
  • Patient capable of understanding the scope of our project or signing informed consent independently

Exclusion criteria

  • Unable to provide informed consent

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Basic science

Study locations

United States · 1 center
  • Stanford Hospital — Stanford

Identifiers

NCT: NCT07226908 · 11354 · 1R01NS137650-01A1

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗