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Recruiting NCT07211529

Intraoperative Paravertebral Block and Postoperative Complications

No phase Interventional Video-assisted Thoracoscopic Surgery (VATS) Lung Cancer (Diagnosis) Pulmonary Infections Respiratory Failure Without Hypercapnia

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Paravertebral Block (PVB).
Who it may be relevant to
Registry conditions: Video-assisted Thoracoscopic Surgery (VATS), Lung Cancer (Diagnosis), Pulmonary Infections, Respiratory Failure Without Hypercapnia. Basic parameters: 18 years — 80 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Perioperative Paravertebral Block Reduces Postoperative Complications in Thoracic Surgery: An Observational Study

Overview

This study aims to evaluate the clinical association between intraoperative paravertebral block and the reduction of postoperative complications following thoracic surgery.

Detailed description

This study is designed as an observational investigation combining both retrospective and prospective components, focusing on patients undergoing thoracic surgery, primarily pulmonary and mediastinal procedures.

Retrospective analysis: We will collect data from patients across multiple campuses of Tongji Hospital who previously underwent thoracic surgery with intraoperative paravertebral block. These cases will be retrospectively analyzed to explore the association between paravertebral block and the reduction of postoperative complications.

Prospective evaluation: For patients enrolled prospectively, we will collect perioperative biochemical parameters, including MMP3, neutrophils, leukocytes, PCT, CRP, and other relevant regulatory factors. Postoperative outcomes will be assessed by recording cough and pain scores, as well as time to first flatus and defecation at 24 and 48 hours after surgery. In addition, patients will be followed for 30 days to document the incidence of postoperative complications.

Clinical correlation: The association between the measured biomarkers and patient outcomes will be systematically evaluated to determine their clinical relevance in predicting prognosis.

Interventions

  • Procedure Paravertebral Block (PVB)
    Participants in this arm will receive a paravertebral nerve block (PVB) performed intraoperatively under ultrasound guidance prior to the thoracic surgical procedure. The block will target the relevant thoracic vertebral levels corresponding to the surgical site. Standard local anesthetic agents will be administered according to institutional protocols. This intervention aims to provide perioperative analgesia, reduce postoperative pain, and potentially decrease the incidence of postoperative co

Primary outcome measures

  • Postoperative Complications [Time frame: 1 to 3 months postoperatively]

Eligibility criteria

Inclusion criteria

  • Male or female participants aged 18 years or older.
  • Scheduled to undergo thoracic surgery via Video-Assisted Thoracoscopic Surgery (VATS) or Robotic-Assisted Thoracoscopic Surgery (RATS), including wedge resection, segmentectomy, lobectomy, or mediastinal surgery.
  • Signed informed consent obtained prior to study participation. -

Exclusion criteria

  • Patients who refuse to provide informed consent.
  • Anesthesiologists who have not received training in ultrasound-guided paravertebral block (PVB-US).
  • History of ipsilateral thoracic surgery.
  • Conversion to open thoracotomy during the procedure.
  • Patients who did not complete the scheduled surgery due to disease progression or medical reasons.
  • Patients who are lost to follow-up or refuse postoperative follow-up. -

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Quadruple blind
Primary purpose
Prevention

Study locations

China · 1 center
  • Tongji Medical College of HUST: Huazhong University of Science and Technology Tongji Medic — Wuhan

Identifiers

NCT: NCT07211529 · TJ-JRB202508092 · TJ-JRB202508092

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗