Urethral Vascularization and Urodynamics
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: 3D Ultrasound.
- Who it may be relevant to
- Registry conditions: Stress Urinary Incontinence, Ultrasound, Vascularisation, Urodynamic Exam. Basic parameters: from 18 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Switzerland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
UVASC Urethral Vascularization and Urodynamics
Overview
The urethra plays a crucial role in maintaining urinary continence. Its complex blood supply is still not well understood. Particularly in the context of urethral pressure. Urethral pressure can be measured by bladder and urethral pressure studies (urodynamic). This study aims to use advanced imaging techniques to analyse the blood supply of the urethra and correlate it to urethral pressure measurements. Elucidating these relationships will improve our understanding of urethral function and malfunction, and ultimately optimise diagnosis and treatment of stress urinary incontinence. A total of 35 participants with stress urinary incontinence and 35 without stress urinary incontinence will be asked to participate in this study.
Interventions
- Diagnostic test 3D Ultrasound
Virtual Organ Computer-aided AnaLysis (VOCAL) to assess flow and velocity characteristics of the urethral blood supply
Primary outcome measures
- Color histogram index (Vascularity Index) [Time frame: Enrollment by the urodynamic examination until the ultrasound measurement (VOCAL) up to 4 weeks]
Eligibility criteria
Inclusion criteria
- Urodynamic examination
- Written informed consent
- Understanding of the German language
- Indicated urodynamic assessment
- Endovaginal and perineal ultrasound feasible
Exclusion criteria
- Urinary tract infections
- Transgender Population
- Pregnancy
- History of incontinence or prolapse surgery
- Pelvic prolapse higher than second degree
- Prior pelvic radiotherapy
- Prior history of gynecologic tumor
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Non-randomized
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
Switzerland · 1 center
- University Hospital Bern, Inselspital — Bern
Publications
- Lone F, Thakar R, Wieczorek AP, Sultan AH, Stankiewicz A. Assessment of urethral vascularity using 2D colour Doppler high-frequency endovaginal ultrasonography in women treated for symptomatic stress urinary incontinence: 1-year prospective follow-up study. Int Urogynecol J. 2016 Jan;27(1):85-92. doi: 10.1007/s00192-015-2800-z. Epub 2015 Aug 5. PMID 26243181
- Liang CC, Chang SD, Chang YL, Wei TY, Wu HM, Chao AS. Three-dimensional power Doppler measurement of perfusion of the periurethral tissue in incontinent women -- a preliminary report. Acta Obstet Gynecol Scand. 2006;85(5):608-13. doi: 10.1080/00016340500342920. PMID 16752242
Identifiers
NCT: NCT07185698 · 2024-01776 · 2024-01776